异常蛋白聚集通过持续但被欺骗的 JAK1-STAT 通路激活加剧了毒性。
Sustained but Decoyed Activation of the JAK1-STAT Pathway by Aberrant Protein Aggregation Exacerbates Proteotoxicity.
机构信息
Division of Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion (M.C., B.P., P.X., M.B., M.T.L., X.W.).
Department of Computer Science, Loyola University Chicago, IL (Y.X.).
出版信息
Circulation. 2024 Oct 15;150(16):1302-1305. doi: 10.1161/CIRCULATIONAHA.124.070067. Epub 2024 Oct 14.
Abstract
Aberrant protein aggregation hijacks phosphorylated STATs and decoys the JAK1-STAT pathway to exacerbate proteotoxicity.
摘要
异常蛋白聚集劫持磷酸化 STAT 并欺骗 JAK1-STAT 途径，从而加剧蛋白毒性。
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Trends Mol Med. 2020 Jul;26(7):639-648. doi: 10.1016/j.molmed.2020.02.007. Epub 2020 Mar 26.
2
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Circulation. 2019 Apr 30;139(18):2085-2088. doi: 10.1161/CIRCULATIONAHA.118.037417.
3
An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels.一种用于鉴定影响心肌细胞聚集水平的新型效应分子的无偏高通量筛选方法。
Circ Res. 2017 Sep 1;121(6):604-616. doi: 10.1161/CIRCRESAHA.117.310945. Epub 2017 Jun 27.
4
JAK redux: a second look at the regulation and role of JAKs in the heart.JAK再探讨：重新审视JAKs在心脏中的调节作用及角色
Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1545-56. doi: 10.1152/ajpheart.00032.2009. Epub 2009 Aug 28.
5
SOCS proteins, cytokine signalling and immune regulation.细胞因子信号抑制蛋白、细胞因子信号传导与免疫调节
Nat Rev Immunol. 2007 Jun;7(6):454-65. doi: 10.1038/nri2093. Epub 2007 May 18.
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