酒精与阿米替林、氟西汀及安慰剂在正常受试者中相互作用的比较研究。

A comparative study of the interactions of alcohol with amitriptyline, fluoxetine and placebo in normal subjects.

Allen D, Lader M, Curran H V

Department of Psychiatry, Institute of Psychiatry, London, England.

Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(1):63-80. doi: 10.1016/0278-5846(88)90062-0.

Abstract

Twelve normal volunteer subjects were given amitriptyline, fluoxetine and placebo in clinically relevant doses, each for a period of 7 days. A minimum of 28 days intervened between each drug treatment. 2. A battery of physiological, psychomotor and subjective tests was administered before drugs and on days 4 and 8. 3. On day 8 a measured dose of alcohol was given and the tests repeated 1 hour and 3 hours later. 4. Before alcohol, little effect was shown on physiological or psychomotor activity. Subjective ratings indicated that amitriptyline was less-well tolerated than fluoxetine. 5. Significant differences were found for many measures after alcohol but there were few differences with respect to the drugs.

摘要

12名正常志愿者受试者接受了临床相关剂量的阿米替林、氟西汀和安慰剂治疗，每种药物治疗持续7天。每次药物治疗之间至少间隔28天。2. 在用药前以及第4天和第8天进行了一系列生理、心理运动和主观测试。3. 在第8天给予一定剂量的酒精，并在1小时和3小时后重复测试。4. 在饮用酒精前，生理或心理运动活动几乎没有受到影响。主观评分表明，阿米替林的耐受性不如氟西汀。5. 饮用酒精后，许多测量指标存在显著差异，但不同药物之间差异不大。