氟西汀和阿米替林对心脏功能的比较效应。
Comparative effects of fluoxetine and amitriptyline on cardiac function.
作者信息
Upward J W, Edwards J G, Goldie A, Waller D G
机构信息
Clinical Pharmacology Group, Southampton General Hospital.
出版信息
Br J Clin Pharmacol. 1988 Oct;26(4):399-402. doi: 10.1111/j.1365-2125.1988.tb03397.x.
Abstract
- The effects of fluoxetine and amitriptyline on the electrocardiogram (ECG) and systolic time intervals (STIs) were measured during a double-blind parallel-group study in depressed patients. 2. ECGs and STIs were measured after a 1 week placebo run-in, following 1 week's treatment with fluoxetine 40 mg daily or amitriptyline 100 mg daily, and then after 3 weeks' treatment with fluoxetine 60-80 mg daily or amitriptyline 150-200 mg daily. 3. Fluoxetine had no effect on the ECG or STIs at any dose. Amitriptyline 150-200 mg daily shortened the sinus cycle length by a mean of 12%, prolonged the PR interval by 8% and the QRS duration by 10%. Amitriptyline did not significantly alter the STIs.
摘要
- 在一项针对抑郁症患者的双盲平行组研究中，测量了氟西汀和阿米替林对心电图（ECG）和收缩期时间间期（STIs）的影响。2. 在为期1周的安慰剂导入期后、每日服用40 mg氟西汀或100 mg阿米替林治疗1周后，以及随后每日服用60 - 80 mg氟西汀或150 - 200 mg阿米替林治疗3周后，测量心电图和收缩期时间间期。3. 氟西汀在任何剂量下对心电图或收缩期时间间期均无影响。每日服用150 - 200 mg阿米替林可使窦性周期长度平均缩短12%，PR间期延长8%，QRS时限延长10%。阿米替林对收缩期时间间期无显著影响。
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本文引用的文献
1
2
Laboratory and clinical observations on chlorpromazine (SKF-2601-A); hemodynamic and toxicological studies.
Am J Med Sci. 1954 Mar;227(3):283-90.
3
Cardiovascular effects of tricyclic antidepressants in depressed patients with chronic heart disease.
N Engl J Med. 1982 Apr 22;306(16):954-9. doi: 10.1056/NEJM198204223061603.
4
Determination of fluoxetine and norfluoxetine in plasma by gas chromatography with electron-capture detection.
Clin Chem. 1982 Oct;28(10):2100-2.
5
Cardiovascular effects of antidepressants.
J Clin Psychiatry. 1982 Nov;43(11 Pt 2):22-9.
6
Trimipramine kinetics and absolute bioavailability: use of gas-liquid chromatography with nitrogen-phosphorus detection.
Clin Pharmacol Ther. 1984 Mar;35(3):348-53. doi: 10.1038/clpt.1984.42.
7
Antidepressants and heart disease.
Br Med J (Clin Res Ed). 1984 Jul 7;289(6436):1-2. doi: 10.1136/bmj.289.6436.1.
8
Fluoxetine and two other serotonin uptake inhibitors without affinity for neuronal receptors.
Biochem Pharmacol. 1983 Apr 1;32(7):1287-93. doi: 10.1016/0006-2952(83)90284-8.
9
The effects of psychotropic drugs on the cardiovascular system.
J Clin Psychiatry. 1982 May;43(5 Pt 2):16-31.
10
Adverse effects of antidepressant drugs. Part 1: monoamine oxidase inhibitors and tricyclics.
Drugs. 1981 Mar;21(3):201-19. doi: 10.2165/00003495-198121030-00002.
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