Dipartimento di Medicina Veterinaria, Via San Costanzo 4, Università degli Studi di Perugia, 06126 Perugia, Italy.
Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle D'Aosta, National Reference Center of Veterinary and Comparative Oncology (CEROVEC), Piazza Borgo Pila, 16129 Genova, Italy.
Res Vet Sci. 2020 Oct;132:167-171. doi: 10.1016/j.rvsc.2020.06.003. Epub 2020 Jun 5.
In horses, squamous cell carcinomas (SCCs) are the most common malignant tumors developing on non-pigmented skin, muco-cutaneous areas, like external genitalia, and, less frequently, in the stomach. Growing evidence suggests Equus caballus papillomavirus type 2 (EcPV2) as causative agent of genital SCCs. Our case report describes a 20-year-old, female, mixed-breed pony with co-occurring vulvar papilloma and in situ carcinoma and gastric SCC. Both lesions were positive for the same EcPV2, as confirmed by DNA sequencing. E6 mRNA expression was observed both in vulvar lesions and gastric SCC, while L1 mRNA was expressed in the vulvar tumor. To the best of the Authors' knowledge, this is the first report of an association between EcPV2 and equine gastric squamous cell carcinoma, with co-occurring EcPV2-positive genital lesions. Further studies are required to assess the real prevalence and the possible role of this viral type in these equine tumors.
在马中，鳞状细胞癌（SCC）是最常见的非色素皮肤、黏膜区域恶性肿瘤，如外阴生殖器，以及较少发生在胃。越来越多的证据表明马乳头状瘤病毒 2 型（EcPV2）是生殖器 SCC 的致病因子。我们的病例报告描述了一例 20 岁、母、混种小马，同时患有外阴乳头瘤和原位癌以及胃 SCC。这两种病变均为同种 EcPV2 阳性，经 DNA 测序证实。在外阴病变和胃 SCC 中均观察到 E6 mRNA 表达，而 L1 mRNA 在外阴肿瘤中表达。据作者所知，这是首例报道 EcPV2 与马胃鳞状细胞癌相关，并伴有 EcPV2 阳性的生殖器官病变。需要进一步的研究来评估这种病毒类型在这些马肿瘤中的真实流行率和可能作用。
