自然杀伤细胞在同种异体移植反应中的作用。
The contribution of natural killer cells to the allograft response.
作者信息
Hoffman R A, Jordan M L, Ascher N L, Simmons R L
机构信息
Department of Surgery, University of Minnesota Hospital, Minneapolis 55455.
出版信息
Transplant Proc. 1988 Apr;20(2):186-8.
PMID:3259031
Abstract
The NK cells and the alloimmune CTL recovered from a rejecting sponge graft both possess the surface determinant AGM1. Both systemic and local treatment of sponge-bearing mice with anti-AGM1, results in severe inhibition of NK activity and alloimmune CTL activity recovered from the graft. From this evidence it is tempting to speculate that cells exhibiting the characteristics of NK cells may differentiate into alloimmune CTL.
摘要
从正在排斥的海绵移植物中回收的自然杀伤（NK）细胞和同种异体免疫细胞毒性T淋巴细胞（CTL）均具有表面决定簇AGM1。用抗AGM1对携带海绵的小鼠进行全身和局部治疗，均会导致从移植物中回收的NK活性和同种异体免疫CTL活性受到严重抑制。根据这一证据，很容易推测具有NK细胞特征的细胞可能分化为同种异体免疫CTL。
Zotero 插件