自然杀伤细胞在同种异体移植反应中的作用。
The role of natural killer cells in the allograft response.
作者信息
Hoffman R A, Jordan M L, Ascher N L, Simmons R L
机构信息
Department of Surgery, University of Minnesota Hospitals, Minneapolis, MN 55455.
出版信息
Transplant Proc. 1987 Feb;19(1 Pt 1):342-4.
NK cells, present in sponge allografts between all genetic barriers tested, are present at the graft site several days before alloimmune CTL are detected. Both NK and alloimmune CTL possess the AGM1 surface marker. Systemic as well as local treatment with AGM1 antisera depletes NK activity as well as alloimmune CTL at the graft site. NK cells may function at the graft site to facilitate development of alloimmune CTL and/or NK cells may themselves differentiate into alloimmune CTL.
在所有测试的遗传屏障之间的海绵同种异体移植物中均存在自然杀伤（NK）细胞，在检测到同种异体免疫细胞毒性T淋巴细胞（CTL）之前几天，NK细胞就已存在于移植物部位。NK细胞和同种异体免疫CTL均具有AGM1表面标志物。用AGM1抗血清进行全身及局部治疗会消耗移植物部位的NK活性以及同种异体免疫CTL。NK细胞可能在移植物部位发挥作用，以促进同种异体免疫CTL的发育，和/或NK细胞自身可能分化为同种异体免疫CTL。
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