Mikata A, Suzuki H, Ohkawa H
Department of Pathology, School of Medicine, Chiba University, Japan.
Acta Pathol Jpn. 1988 Jan;38(1):47-58. doi: 10.1111/j.1440-1827.1988.tb01071.x.
Twenty-eight cases of B cell lymphoma were studied immunohistochemically utilizing a panel of monoclonal antibodies. Of 27 cases tested, 26 were B-1-positive and 22 of 24 cases were HLA-DR positive. There were eight BA-1-positive cases, including one follicular lymphoma, and 10 J-5-positive cases including five diffuse large cell lymphomas. Some of the J-5-positive diffuse large cell lymphomas were considered to be of follicular center cell origin. Infiltration and distribution of non-neoplastic T cell subsets, BA-1-positive B cells, dendritic reticulum cells, Langerhans cells and HNK cells showed close similarity between the structure of follicular lymphomas and that of the reactive follicles. Such similarity to the normal counterpart structure was less apparent in diffuse lymphomas, especially in the large cell type. These findings were interpreted to be an expression of different degrees of neoplastic deviation. There was evidence to suggest that, regardless of the histological classification, a large number of infiltrating non-neoplastic T cells was related to good prognosis.
利用一组单克隆抗体对28例B细胞淋巴瘤进行了免疫组织化学研究。在检测的27例病例中，26例B-1阳性，24例中的22例HLA-DR阳性。有8例BA-1阳性病例，包括1例滤泡性淋巴瘤，10例J-5阳性病例，包括5例弥漫性大细胞淋巴瘤。一些J-5阳性弥漫性大细胞淋巴瘤被认为起源于滤泡中心细胞。非肿瘤性T细胞亚群、BA-1阳性B细胞、树突状网状细胞、朗格汉斯细胞和HNK细胞的浸润和分布在滤泡性淋巴瘤结构与反应性滤泡结构之间显示出密切相似性。这种与正常对应结构的相似性在弥漫性淋巴瘤中不太明显，尤其是在大细胞型中。这些发现被解释为不同程度肿瘤性偏离的表现。有证据表明，无论组织学分类如何，大量浸润的非肿瘤性T细胞与良好预后相关。
