Sato Y, Ito M, Morise K, Saito Y, Kusugami K
First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Virchows Arch. 1996 Dec;429(6):377-82. doi: 10.1007/BF00198443.
To determine whether primary B-cell gastric lymphoma (GL) is one entity, we examined the expression of three adhesion molecules in the microvasculature of lymphomas. Stromal cells, including vascular endothelial cells, within lymphoid follicies of the gastric mucosa were also investigated. Twenty-two surgical specimens of GL were classified into low-grade malignant lymphoma arising from mucosa-associated lymphoid tissue (low-grade lymphoma, n = 9), and high-grade malignant lymphoma with (secondary high-grade lymphoma, n = 6) or without (primary high-grade lymphoma, n = 7) a low-grade component. The proportion of venules positive for ELAM-1 or VCAM-1 was significantly higher (P < 0.001) in primary high-grade lymphoma than in low-grade and secondary high-grade lymphomas. In gastric lymphoid follicles, the stromal cells of the germinal centre (GC) were positive for ICAM-1, ELAM-1, and VCAM-1, but the stromal cells of the marginal zone (MZ) were positive only for ICAM-1. We found two patterns of adhesion molecule expression in gastric lymphoid follicles, the MZ pattern and the GC pattern. Low-grade and secondary high-grade lymphomas, which had the MZ pattern, might be of MZ-cell lineage, but most primary high-grade lymphomas, which had the GC pattern, might be of follicular centre cell lineage.
为了确定原发性B细胞性胃淋巴瘤（GL）是否为单一实体，我们检测了淋巴瘤微血管中三种黏附分子的表达。同时也研究了胃黏膜淋巴滤泡内的基质细胞，包括血管内皮细胞。22例GL手术标本被分为起源于黏膜相关淋巴组织的低级别恶性淋巴瘤（低级别淋巴瘤，n = 9），以及伴有（继发性高级别淋巴瘤，n = 6）或不伴有（原发性高级别淋巴瘤，n = 7）低级别成分的高级别恶性淋巴瘤。原发性高级别淋巴瘤中ELAM-1或VCAM-1阳性的小静脉比例显著高于低级别和继发性高级别淋巴瘤（P < 0.001）。在胃淋巴滤泡中，生发中心（GC）的基质细胞ICAM-1、ELAM-1和VCAM-1呈阳性，但边缘区（MZ）的基质细胞仅ICAM-1呈阳性。我们在胃淋巴滤泡中发现了两种黏附分子表达模式，即MZ模式和GC模式。具有MZ模式的低级别和继发性高级别淋巴瘤可能起源于MZ细胞系，但大多数具有GC模式的原发性高级别淋巴瘤可能起源于滤泡中心细胞系。
