Xiong Zhihui, Wang Xinchen, Jiang Sicong, Jin Meiyuan, Chen Wenzeng
Department of Obstetrics, Tongde Hospital of Zhejiang Province, Hangzhou.
Department of Thoracic Surgery, Medical College of Nanchang University, Nanchang, China.
Medicine (Baltimore). 2020 Jun 26;99(26):e20744. doi: 10.1097/MD.0000000000020744.
An association between circulating pentraxin-3 (PTX3) and the risk of preeclampsia (PE) remains to be established. We performed a meta-analysis of observational studies to evaluate their relationship.The PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and WanFang databases were searched for related observational studies evaluating PTX3 and PE risk. A random-effects or a fixed-effects model was used in the meta-analysis, depending on the heterogeneity among the included studies.Nine case-control studies were included, with 396 PE patients and 438 controls. The results showed that PTX3 was significantly higher in pregnant women with PE as compared to those without PE (standardized mean difference [SMD] = 2.48, P < .001), with significant heterogeneity (I2 = 98%), particularly for those over 30 years old (SMD = 3.75, P < .001). Subsequent analyses showed that patients with severe or early-onset PE had higher PTX3 levels compared to those with mild or late-onset PE (SMD = 0.93, P = .01), suggesting that PTX3 may be a marker of PE severity. The association between PTX3 and PE was not significantly affected by the statistical method used. Sensitivity analyses by omitting one study at a time did not significantly affect the results. However, the funnel plots were asymmetric, suggesting the potential existence of publication bias.PTX3 may be related to the risk and severity of PE in pregnant women. These results should be evaluated and confirmed in cohort studies.
循环五聚体蛋白3（PTX3）与子痫前期（PE）风险之间的关联尚待确定。我们进行了一项观察性研究的荟萃分析，以评估它们之间的关系。检索了PubMed、Embase、Cochrane图书馆、中国知网和万方数据库，查找评估PTX3与PE风险的相关观察性研究。根据纳入研究之间的异质性，在荟萃分析中使用随机效应模型或固定效应模型。纳入了9项病例对照研究，包括396例PE患者和438例对照。结果显示，与无PE的孕妇相比，患有PE的孕妇PTX3显著更高（标准化均值差[SMD]=2.48，P<0.001），存在显著异质性（I2=98%），尤其是30岁以上的孕妇（SMD=3.75，P<0.001）。随后的分析表明，与轻度或晚发型PE患者相比，重度或早发型PE患者的PTX3水平更高（SMD=0.93，P=0.01），这表明PTX3可能是PE严重程度的一个标志物。PTX3与PE之间的关联不受所用统计方法的显著影响。每次剔除一项研究进行的敏感性分析对结果没有显著影响。然而，漏斗图不对称，提示可能存在发表偏倚。PTX3可能与孕妇PE的风险和严重程度有关。这些结果应在队列研究中进行评估和确认。
