Le Huu Y, Pham Dinh Phuc, Nguyen Khac Tuyen, Hoang Van Ai, Trinh The Son, Do Quyet
Center of Respiratory Diseases, 103 Military Hospital.
Center of Oncology.
Medicine (Baltimore). 2020 Jun 26;99(26):e20869. doi: 10.1097/MD.0000000000020869.
Pulmonary sclerosing pneumocytoma (PSP) is a rare benign tumor of the lung, mostly presented in Asian middle-aged women. Initially, it was considered as a vascular origin tumor, but then research evidence showed that it was derived from natural epithelial tissue. On imaging, this tumor may be found as a solitary well-circumscribed lung parenchymal lesion, and is often located in juxtapleural or juxtafissural positions. On histopathology, it consists of cuboidal surface cells and stromal round cells, both of which are positive for thyroid transcription factor-1. Here we report a case of a young PSP male patient and review the relevant literature in order to improve our understanding of this disease.
An 18-year-old man was referred to our hospital after accidentally finding a lesion on chest X-ray. Contrast-enhanced computed tomography showed a soft tissue mass with homogeneous enhancement in the left lower lobe posterior segment.
The diagnosis of PSPs was confirmed by histopathological examination.
The patient underwent a thoracoscopic wedge resection and was followed-up after that. One month later, he had good performance status with no recurrent tumors.
PSP in a young man is really uncommon, and is confused with malignant tumors. A histopathological examination is considered as the diagnostic gold standard for this uncommon tumor. Surgery is the main treatment.
肺硬化性细胞瘤(PSP)是一种罕见的肺良性肿瘤,多见于亚洲中年女性。最初,它被认为是一种起源于血管的肿瘤,但后来的研究证据表明它起源于天然上皮组织。在影像学上,该肿瘤可表现为孤立的、边界清晰的肺实质病变,常位于胸膜旁或叶间裂附近位置。在组织病理学上,它由立方表面细胞和基质圆形细胞组成,两者甲状腺转录因子-1均呈阳性。在此我们报告一例年轻的PSP男性患者病例,并复习相关文献以增进我们对该疾病的了解。
一名18岁男性在胸部X线偶然发现病变后转诊至我院。增强计算机断层扫描显示左肺下叶后段有一软组织肿块,强化均匀。
PSP的诊断经组织病理学检查得以证实。
患者接受了胸腔镜楔形切除术,术后进行随访。1个月后,他状态良好,无肿瘤复发。
年轻人患PSP确实罕见,且易与恶性肿瘤混淆。组织病理学检查被认为是这种罕见肿瘤的诊断金标准。手术是主要治疗方法。