少女乳房巨大原发性血管肉瘤：尸检后诊断 1 例报告。
Giant primary angiosarcoma of an adolescent girl's breast diagnosed postmortem: a case report.
机构信息
Department of Pathology, University Teaching Hospital of Lomé, Lomé, BP 1515, Togo.
Department of Pathology, University Teaching Hospital of Parakou, Cotonou, Bénin.
出版信息
J Med Case Rep. 2020 Jun 27;14(1):80. doi: 10.1186/s13256-020-02403-y.
BACKGROUND
Angiosarcoma is an endothelial malignant tumor; angiosarcoma located in the breast is extremely rare, less than 0.01%. We report a case of a giant angiosarcoma diagnosed postmortem in a 16-year-old girl in a resource-constrained country.
CASE PRESENTATION
A 16-year-old black African girl was admitted for altered consciousness and a left breast tumor. She was admitted in a state of apparent death. Her death was confirmed on clinical examination. A postmortem biopsy of the mammary tumor showed standard histology of a proliferation of fusiform or rounded tumor cells in places, which were not very cohesive with marked anisokaryosis and numerous foci of tumor necrosis. Immunohistochemistry showed a positivity of CD31 and factor VIII markers with a proliferation index (Ki-67) estimated at 30%.
CONCLUSION
Primary angiosarcoma of the breast is exceptional in adolescents and has a poor prognosis, especially in countries with limited resources.
背景
血管肉瘤是一种内皮恶性肿瘤；发生于乳腺的血管肉瘤极为罕见，发病率不足 0.01%。我们报告了一例资源匮乏国家中，16 岁少女尸检诊断的巨大血管肉瘤病例。
病例介绍
一名 16 岁的黑人少女因意识改变和左侧乳腺肿瘤入院。入院时已处于明显的死亡状态。临床检查确认了她的死亡。乳腺肿瘤的尸检活检显示，在某些部位存在梭形或圆形肿瘤细胞的标准组织学增生，这些细胞不太具有细胞间黏附性，存在明显的非整倍体和多处肿瘤坏死灶。免疫组织化学显示 CD31 和因子 VIII 标志物阳性，增殖指数（Ki-67）估计为 30%。
结论
青少年的原发性乳腺血管肉瘤罕见，预后较差，特别是在资源有限的国家。
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