Gracia Baena J M, Calaf Vall I, Zielonka M, Marsal Mora J R, Godoy P, Worner Diz F
Servei de Cirurgia Cardíaca d'Adults, Hospital Universitari Vall d'Hebron, Barcelona, España; Unitat d'Epidemiologia Aplicada, Departament de Cirurgia, Universitat de Lleida, Lérida, España.
Servei de Cardiologia, Hospital Universitari Arnau de Vilanova, Lérida, España.
Rev Clin Esp. 2021 May;221(5):249-257. doi: 10.1016/j.rce.2020.01.010. Epub 2020 Jun 24.
Aortic stricture (AS) is one of the most prevalent cardiovascular diseases in individuals 65 years of age or older. A number of epidemiological studies have suggested that certain cardiovascular risk factors (CRFs) and comorbidities could be associated with AS. The aim of this study was to evaluate the association between CRFs and comorbidities and severe symptomatic AS in individuals 65 years of age or older in a Spanish healthcare region.
We conducted an epidemiological case-control study from a single primary care centre. We collected information on exposure to CRFs and comorbidities and determined their association with AS, employing adjusted odds ratios (OR) and multiple logistic regression models.
The study included 102 cases (mean age, 77.6 years) and 221 controls (mean age, 75.5 years). The CRFs significantly associated with severe symptomatic AS were hypercholesterolaemia (OR, 2.67; p<.001), tobacco use (OR, 2.60; p<.001), hypertension (OR, 2.41; p=.010) and low HDL cholesterol readings (OR, 2.20; p=.007). The comorbidities significantly associated with severe symptomatic AS were carotid stenosis (OR, 14.5; p=.017), stroke (OR, 4.14; p=.024), chronic renal failure (OR, 3.78; p<.001) and low haemoglobin levels (OR, 0.76; p<.001).
Hypercholesterolaemia, tobacco use, arterial hypertension and low HDL cholesterol levels are the CRFs with a greater risk of severe AS. Furthermore, this disease is associated with a number of comorbidities (chronic renal failure, stroke, carotid stenosis and low haemoglobin levels), which could be markers of AS.
主动脉狭窄（AS）是65岁及以上人群中最常见的心血管疾病之一。多项流行病学研究表明，某些心血管危险因素（CRF）和合并症可能与AS有关。本研究的目的是评估西班牙一个医疗保健地区65岁及以上人群中CRF和合并症与严重症状性AS之间的关联。
我们在一个初级保健中心进行了一项流行病学病例对照研究。我们收集了有关CRF暴露和合并症的信息，并采用调整后的比值比（OR）和多元逻辑回归模型确定它们与AS的关联。
该研究包括102例病例（平均年龄77.6岁）和221例对照（平均年龄75.5岁）。与严重症状性AS显著相关的CRF是高胆固醇血症（OR，2.67；p<0.001）、吸烟（OR，2.60；p<0.001）、高血压（OR，2.41；p = 0.010）和低高密度脂蛋白胆固醇读数（OR，2.20；p = 0.007）。与严重症状性AS显著相关的合并症是颈动脉狭窄（OR，14.5；p = 0.017）、中风（OR，4.14；p = 0.024）、慢性肾功能衰竭（OR，3.78；p<0.001）和低血红蛋白水平（OR，0.76；p<0.001）。
高胆固醇血症、吸烟、动脉高血压和低高密度脂蛋白胆固醇水平是严重AS风险较高的CRF。此外，这种疾病与多种合并症（慢性肾功能衰竭、中风、颈动脉狭窄和低血红蛋白水平）有关，这些合并症可能是AS的标志物。
