Servei de Cirurgia Cardíaca d'Adults, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Unitat d'Epidemiologia Aplicada, Departament de Cirurgia, Universitat de Lleida, Lleida, Spain.
Servei de Cardiologia, Hospital Universitari Arnau de Vilanova, Lleida, Spain.
Rev Clin Esp (Barc). 2021 May;221(5):249-257. doi: 10.1016/j.rceng.2020.01.009. Epub 2021 Mar 19.
Aortic stricture (AS) is one of the most prevalent cardiovascular diseases in individuals 65 years of age or older. A number of epidemiological studies have suggested that certain cardiovascular risk factors (CRFs) and comorbidities could be associated with AS. The aim of this study was to evaluate the association between CRFs and comorbidities and severe symptomatic AS in individuals 65 years of age or older in a Spanish healthcare region.
We conducted an epidemiological case-control study from a single primary care centre. We collected information on exposure to CRFs and comorbidities and determined their association with AS, employing adjusted odds ratios (OR) and multiple logistic regression models.
The study included 102 cases (mean age, 77.6 years) and 221 controls (mean age, 75.5 years). The CRFs significantly associated with severe symptomatic AS were hypercholesterolaemia (OR, 2.67; p < .001), tobacco use (OR, 2.60; p < .001), hypertension (OR, 2.41; p = .010) and low HDL cholesterol readings (OR, 2.20; p = .007). The comorbidities significantly associated with severe symptomatic AS were carotid stenosis (OR, 14.5; p = .017), stroke (OR, 4.14; p = .024), chronic renal failure (OR, 3.78; p < .001) and low haemoglobin levels (OR, 0.76; p < .001).
Hypercholesterolaemia, tobacco use, arterial hypertension and low HDL cholesterol levels are the CRFs with a greater risk of severe AS. Furthermore, this disease is associated with a number of comorbidities (chronic renal failure, stroke, carotid stenosis and low haemoglobin levels), which could be markers of AS.
主动脉狭窄（AS）是 65 岁及以上人群中最常见的心血管疾病之一。多项流行病学研究表明，某些心血管危险因素（CRFs）和合并症可能与 AS 相关。本研究旨在评估西班牙某一医疗区域内 65 岁及以上人群中 CRFs 和合并症与严重症状性 AS 之间的关联。
我们进行了一项来自单一初级保健中心的流行病学病例对照研究。我们收集了暴露于 CRFs 和合并症的信息，并使用调整后的优势比（OR）和多变量逻辑回归模型确定了它们与 AS 的关联。
该研究纳入了 102 例病例（平均年龄 77.6 岁）和 221 例对照（平均年龄 75.5 岁）。与严重症状性 AS 显著相关的 CRFs 包括高胆固醇血症（OR，2.67；p<0.001）、吸烟（OR，2.60；p<0.001）、高血压（OR，2.41；p=0.010）和低高密度脂蛋白胆固醇水平（OR，2.20；p=0.007）。与严重症状性 AS 显著相关的合并症包括颈动脉狭窄（OR，14.5；p=0.017）、中风（OR，4.14；p=0.024）、慢性肾衰竭（OR，3.78；p<0.001）和低血红蛋白水平（OR，0.76；p<0.001）。
高胆固醇血症、吸烟、动脉高血压和低高密度脂蛋白胆固醇水平是严重 AS 风险更高的 CRFs。此外，这种疾病与多种合并症（慢性肾衰竭、中风、颈动脉狭窄和低血红蛋白水平）相关，这些合并症可能是 AS 的标志物。
