Biological Psychology Lab, Department of Psychology, School of Medicine and Health Sciences, Research Center Neurosensory Science and Systems, Carl von Ossietzky University Oldenburg, 26111, Oldenburg, Germany.
Department of Psychology, University of Lübeck, 23562, Lübeck, Germany.
Sci Rep. 2020 Jun 26;10(1):10422. doi: 10.1038/s41598-020-67162-8.
Behavioral effects of transcranial magnetic stimulation (TMS) often show substantial differences between subjects. One factor that might contribute to these inter-individual differences is the interaction of current brain states with the effects of local brain network perturbation. The aim of the current study was to identify brain regions whose connectivity before and following right parietal perturbation affects individual behavioral effects during a visuospatial target detection task. 20 subjects participated in an fMRI experiment where their brain hemodynamic response was measured during resting state, and then during a visuospatial target detection task following 1 Hz rTMS and sham stimulation. To select a parsimonious set of associated brain regions, an elastic net analysis was used in combination with a whole-brain voxel-wise functional connectivity analysis. TMS-induced changes in accuracy were significantly correlated with the pattern of functional connectivity during the task state following TMS. The functional connectivity of the left superior temporal, angular, and precentral gyri was identified as key explanatory variable for the individual behavioral TMS effects. Our results suggest that the brain must reach an appropriate state in which right parietal TMS can induce improvements in visual target detection. The ability to reach this state appears to vary between individuals.
经颅磁刺激（TMS）的行为效应在不同个体间常常存在显著差异。导致这些个体间差异的一个因素可能是大脑当前状态与局部脑网络干扰效应的相互作用。本研究旨在确定在右顶叶受到干扰前后其连通性会影响个体在视觉空间目标检测任务中行为效应的脑区。20 名被试参与了 fMRI 实验，在静息状态下测量了他们的大脑血液动力学反应，然后在接受 1Hz rTMS 和假刺激后进行视觉空间目标检测任务。为了选择一套简洁的相关脑区，我们使用弹性网络分析结合全脑体素功能连通性分析。TMS 诱导的准确性变化与 TMS 后任务状态的功能连通性模式显著相关。左颞上回、角回和中央前回的功能连通性被确定为个体行为 TMS 效应的关键解释变量。我们的研究结果表明，大脑必须达到适当的状态，以便右顶叶 TMS 可以提高视觉目标检测的准确性。达到这种状态的能力似乎在个体之间存在差异。
