KHK inhibition for the treatment of hereditary fructose intolerance and nonalcoholic fatty liver disease: a double-edged sword.
作者信息
Pinheiro Franciele Cabral, Sperb-Ludwig Fernanda, Schwartz Ida Vanessa Doederlein
机构信息
Graduate Program in Genetics and Molecular Biology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul RS, Brazil.
BRAIN Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil.
出版信息
Cell Mol Life Sci. 2020 Sep;77(17):3465-3466. doi: 10.1007/s00018-020-03575-y. Epub 2020 Jun 26.
Abstract
摘要
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KHK inhibition for the treatment of hereditary fructose intolerance and nonalcoholic fatty liver disease: a double-edged sword.抑制己糖激酶以治疗遗传性果糖不耐受症和非酒精性脂肪性肝病：一把双刃剑。
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本文引用的文献
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Fructose-mediated effects on gene expression and epigenetic mechanisms associated with NAFLD pathogenesis.果糖介导的与 NAFLD 发病机制相关的基因表达和表观遗传机制的作用。
Cell Mol Life Sci. 2020 Jun;77(11):2079-2090. doi: 10.1007/s00018-019-03390-0.
2
Recent advances in the pathogenesis of hereditary fructose intolerance: implications for its treatment and the understanding of fructose-induced non-alcoholic fatty liver disease.遗传性果糖不耐受发病机制的最新进展：对其治疗和果糖诱导的非酒精性脂肪性肝病认识的影响。
Cell Mol Life Sci. 2020 May;77(9):1709-1719. doi: 10.1007/s00018-019-03348-2. Epub 2019 Nov 12.
3
Daily Fructose Traces Intake and Liver Injury in Children with Hereditary Fructose Intolerance.儿童遗传性果糖不耐受症中果糖每日微量摄入与肝损伤。
Nutrients. 2019 Oct 7;11(10):2397. doi: 10.3390/nu11102397.
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Fructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism.果糖吸收不良通过改变微生物群落组成和代谢诱导回肠和盲肠中胆囊收缩素的表达。
FASEB J. 2019 Jun;33(6):7126-7142. doi: 10.1096/fj.201801526RR. Epub 2019 Apr 2.
5
Non-alcoholic fatty liver in hereditary fructose intolerance.遗传性果糖不耐受中的非酒精性脂肪肝。
Clin Nutr. 2020 Feb;39(2):455-459. doi: 10.1016/j.clnu.2019.02.019. Epub 2019 Feb 15.
6
Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice.酮己糖激酶 C 阻断可改善果糖敏感小鼠中果糖诱导的代谢功能障碍。
J Clin Invest. 2018 Jun 1;128(6):2226-2238. doi: 10.1172/JCI94427. Epub 2018 Apr 23.
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Inborn Errors of Metabolism with Hepatopathy: Metabolism Defects of Galactose, Fructose, and Tyrosine.伴有肝病的先天性代谢缺陷：半乳糖、果糖和酪氨酸的代谢缺陷
Pediatr Clin North Am. 2018 Apr;65(2):337-352. doi: 10.1016/j.pcl.2017.11.008.
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The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids.小肠将膳食果糖转化为葡萄糖和有机酸。
Cell Metab. 2018 Feb 6;27(2):351-361.e3. doi: 10.1016/j.cmet.2017.12.016.
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