Greenwood Genetic Center, Greenwood, SC, USA.
J.C. Self Research Institute of Human Genetics, Greenwood Genetic Center, 113 Gregor Mendel Circle, Greenwood, SC, 29646, USA.
J Autism Dev Disord. 2021 Feb;51(2):677-684. doi: 10.1007/s10803-020-04568-3.
The course of 187 individuals ages 3-21 years with Autistic Disorder was traced through a period of 20 years (enrollment: 1995-1998, follow up: 2014-2019). Specific genetic and environmental causes were identified in only a minority. Intellectual disability coexisted in 84%. Few became independent with 99% living at home with relatives, in disability group homes or in residential facilities. Seven individuals (3.7%) attained postsecondary education, two receiving baccalaureate degrees, two receiving associate degrees, and three receiving certificates from college disability programs. It may be anticipated that the long term outcome for individuals currently diagnosed with Autism Spectrum Disorder (ASD) will be substantially better than for individuals with Autistic Disorder in this cohort.
对 187 名年龄在 3-21 岁之间的自闭症患者的病程进行了 20 年的跟踪调查（入组时间：1995-1998 年，随访时间：2014-2019 年）。只有少数患者确定了特定的遗传和环境病因。84%的患者伴有智力障碍。只有极少数人能够独立生活，99%的人仍然与亲属一起居住在残疾人家属院或住所设施中。只有 7 人（3.7%）接受了中学后教育，其中 2 人获得学士学位，2 人获得副学士学位，3 人获得大学残疾项目证书。可以预期，目前被诊断为自闭症谱系障碍（ASD）的个体的长期预后将明显好于该队列中的自闭症患者。
