Wong V C, Lam S T
Department of Paediatrics, University of Hong Kong, Pokfulam.
Pediatr Neurol. 1992 Jul-Aug;8(4):272-4. doi: 10.1016/0887-8994(92)90364-5.
Chromosome analysis was performed in 105 Chinese children (96 boys, 9 girls) with autistic spectrum disorder to assess fragile X positivity. Seventy percent of these autistic children were mentally retarded. None of the children in the infantile autism group (N = 75) had fragile X positivity. Two boys in the autistic condition group (N = 30) had clinical features and chromosomal positivity for fragile X syndrome. The low (2%) prevalence rate of fragile X positivity in children with different degrees of expressivity of autistic features may be related to other factors rather than to pure autistic characteristics per se.
对105名患有自闭症谱系障碍的中国儿童（96名男孩，9名女孩）进行了染色体分析，以评估脆性X染色体阳性情况。这些自闭症儿童中有70%存在智力发育迟缓。婴儿自闭症组（n = 75）的儿童均无脆性X染色体阳性。自闭症状态组（n = 30）中有两名男孩具有脆性X综合征的临床特征和染色体阳性。在具有不同程度自闭症特征表达的儿童中，脆性X染色体阳性的低患病率（2%）可能与其他因素有关，而非单纯与自闭症特征本身相关。
