应用长期指数模型分析白血病患者的生存率。
Analyzing Survival Rate of Leukemia Patients Applying Long Term Exponential Model.
机构信息
Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Taleghani Bone Marrow Transplantation Center, Shahid Beheshti University of Medical Science, Tehran, Iran.
出版信息
Asian Pac J Cancer Prev. 2020 Jun 1;21(6):1539-1543. doi: 10.31557/APJCP.2020.21.6.1539.
BACKGROUND
Making progressin treatment of all branches of cancers has increasedthe percent of patients that never experience the event of interest. These cases are called immune or cure and models for handling the data included cure fraction rate, are referred to as cure model or long-term survival models.
METHODS
The data for this historical cohort study, were collected from leukemia patients diagnosed between 2007 to 2014 and followed up until 2016 in Taleghani hospital and received BMT (Bone Marrow Transplant). Some data had to be excluded because of incomplete information. Using recorded files mostly and phone calls rarely, were made to confirm whether the patients were still alive or not. Death due to leukemia was regarded as interested event. Analysis were performed by R version 3.4.1and Stata version 14.
RESULTS
Number of recurrents after receiving BMT, pre-transplant Hb and age at diagnosis were found as significant prognostics of survival time. HD patients had the highest 5-years overall survival in category of diagnosis type with 81.3%. Cure fraction was estimated to be 64.1%.
CONCLUSION
According to high percentage of censoring, using long-term model had better fit.
背景
所有癌症治疗分支的进展都提高了从未经历过感兴趣事件的患者比例。这些病例被称为免疫或治愈，用于处理数据的模型被称为治愈分数率，即治愈模型或长期生存模型。
方法
本历史队列研究的数据来自 2007 年至 2014 年间诊断的白血病患者，并在 2016 年之前在 Taleghani 医院接受 BMT（骨髓移植）。由于信息不完整，一些数据被排除在外。主要通过记录文件，偶尔通过电话，以确认患者是否仍然存活。白血病导致的死亡被视为感兴趣的事件。使用 R 版本 3.4.1 和 Stata 版本 14 进行分析。
结果
接受 BMT 后复发的次数、移植前 Hb 和诊断时的年龄被发现是生存时间的重要预后因素。在诊断类型类别中，HD 患者的 5 年总生存率最高，为 81.3%。估计治愈分数为 64.1%。
结论
根据高比例的删失，使用长期模型拟合效果更好。
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