Division of Infectious Diseases, Keck School of Medicine at the University of Southern California (USC), 2020 Zonal Avenue RM 430, Los Angeles, CA 90033, USA.
Pathog Dis. 2020 Jul 1;78(5). doi: 10.1093/femspd/ftaa030.
There is considerable literature on the threat of antibiotic resistance and its impact on morbidity. However, an under-studied consideration is how carriage of these antibiotic resistant bacteria persist in an individual. The duration that a person harbors a resistant organism is critical in guiding future antimicrobial therapy. Key unexplored questions are the rate of clearance of these organisms and what drives their persistence. This paper attempts to examine these questions and offers some initial answers as well as avenues for further study.
关于抗生素耐药性的威胁及其对发病率的影响,已经有相当多的文献。然而,一个研究不足的考虑因素是,这些携带抗生素耐药菌的个体是如何持续存在的。一个人携带耐药菌的时间对于指导未来的抗菌治疗至关重要。尚未得到充分研究的关键问题是这些生物体的清除速度以及是什么驱动它们的持续存在。本文试图探讨这些问题,并提供一些初步的答案以及进一步研究的途径。