Department of Obstetrics and Gynecology, Division of Perinatology, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey.
J Ultrasound Med. 2021 Jan;40(1):123-128. doi: 10.1002/jum.15382. Epub 2020 Jun 27.
To investigate the pons anteroposterior diameter (APD) and cerebellar vermis craniocaudal diameter (CCD) of fetuses with Down syndrome (DS).
This was a prospective observational study including 200 low-risk pregnancies and 18 pregnancies with fetuses who had DS. A midsagittal view was obtained to measure the pons APD and cerebellar vermis CCD. Gestational age-related 5th, mean, and 95th percentiles for the pons APD and cerebellar vermis CCD between 18 and 32 weeks' gestation were created from the low-risk population. Each measurement of a fetus with DS was plotted on growth charts, and those below the 5th percentile for gestational age were considered small.
The pons APD and cerebellar vermis CCD measurements were below the 5th percentile for gestational age in 7 of the 18 (38.8%) fetuses with DS. Fetuses who had pons APDs below the 5th percentile for gestational age also had cerebellar vermis CCDs below the 5th percentile. Fetuses who had pons and cerebellar vermis measurements below the 5th percentile for gestational age on the initial examination continued to have small measurements during follow-up.
Fetal pons and cerebellar vermis abnormalities could be observed prenatally in fetuses with DS, which could help in the antenatal counseling and postnatal follow-up of such pregnancies.
研究唐氏综合征（DS）胎儿脑桥前后径（APD）和小脑蚓部颅尾径（CCD）。
这是一项前瞻性观察研究，纳入了 200 例低危妊娠和 18 例唐氏综合征胎儿妊娠。获取正中矢状切面以测量脑桥 APD 和小脑蚓部 CCD。从低危人群中创建了 18-32 孕周脑桥 APD 和小脑蚓部 CCD 的第 5、平均和 95 百分位的与胎龄相关的参考值。唐氏综合征胎儿的每个测量值均绘制在生长图表上，低于胎龄第 5 百分位的被认为是小的。
18 例（38.8%）唐氏综合征胎儿中有 7 例脑桥 APD 和小脑蚓部 CCD 测量值低于胎龄第 5 百分位。脑桥 APD 低于胎龄第 5 百分位的胎儿小脑蚓部 CCD 也低于第 5 百分位。在初始检查时脑桥和小脑蚓部测量值低于胎龄第 5 百分位的胎儿在随访期间继续出现较小的测量值。
唐氏综合征胎儿可在产前观察到胎儿脑桥和小脑蚓部异常，这有助于此类妊娠的产前咨询和产后随访。
