Division of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, UK.
Cell Microbiol. 2020 Sep;22(9):e13241. doi: 10.1111/cmi.13241. Epub 2020 Jul 19.
The Type VI secretion system (T6SS) is a protein translocation nanomachine widespread among Gram-negative bacteria and used as a means to deliver effectors directly into target bacterial or eukaryotic cells. These effectors have a wide variety of functions within target cells that ultimately help the secreting cell gain a competitive fitness advantage. Here, we discuss the different ways in which these effectors can be delivered by the T6SS and the diverse mechanisms by which they exert their noxious action upon recipient cells. We also highlight the existence of roles for T6SS effectors beyond simply the killing of neighbouring cells.
VI 型分泌系统（T6SS）是一种广泛存在于革兰氏阴性菌中的蛋白质转运纳米机器，被用作将效应器直接递送至靶细菌或真核细胞的手段。这些效应器在靶细胞内具有多种功能，最终帮助分泌细胞获得竞争适应性优势。在这里，我们讨论了 T6SS 输送这些效应器的不同方式，以及它们对靶细胞发挥有害作用的不同机制。我们还强调了 T6SS 效应器的作用不仅限于简单地杀死邻近细胞。
