甲状旁腺切除术治疗对钙敏感受体治疗抵抗的继发性甲状旁腺功能亢进症的手术效果：一项回顾性单中心队列研究。
Surgical outcomes of parathyroidectomy for secondary hyperparathyroidism resistant to calcimimetic treatment: A retrospective single-center cohort study.
机构信息
Department of Transplantation and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan.
Department of Pathology, Aichi Medical University School of Medicine, Nagakute, Japan.
出版信息
Ther Apher Dial. 2021 Apr;25(2):188-196. doi: 10.1111/1744-9987.13553. Epub 2020 Aug 14.
To evaluate the surgical outcomes of parathyroidectomy (PTx) for secondary hyperparathyroidism (SHPT) resistant to calcimimetic treatment, we retrospectively studied 187 patients with SHPT who had no history of calcimimetic treatment (NCMT) (NCMT group) and 186 patients with SHPT who were resistant to calcimimetic treatment (RCMT) (RCMT group). Success rate and operative time of PTx were compared among the two groups. Operative time was significantly longer in the RCMT group than in the NCMT group (180 vs 158 minutes, P < .001), but the difference was attenuated after multivariate adjustment including the weight of the largest parathyroid gland. No significant differences were observed in success rate of PTx (90.9% vs 91.4%, P = 1.000) between the two groups. In patients with SHPT who are resistant to calcimimetic treatment, operative time could be elongated but success rate of PTx remains unchanged.
为了评估甲状旁腺切除术（PTx）治疗对钙敏感受体治疗抵抗的继发性甲状旁腺功能亢进症（SHPT）的手术效果，我们回顾性研究了 187 例无钙敏感受体治疗史（NCMT）的 SHPT 患者（NCMT 组）和 186 例对钙敏感受体治疗抵抗的 SHPT 患者（RCMT 组）。比较两组患者的 PTx 成功率和手术时间。RCMT 组的手术时间明显长于 NCMT 组（180 分钟比 158 分钟，P<0.001），但在包括最大甲状旁腺重量在内的多变量调整后，差异减弱。两组患者的 PTx 成功率无显著差异（90.9%比 91.4%，P=1.000）。在对钙敏感受体治疗抵抗的 SHPT 患者中，手术时间可能延长，但 PTx 的成功率保持不变。
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