熊果酸对进行高蛋白饮食和抗阻训练的活跃男性的肌肉力量和质量没有额外的影响：一项双盲和安慰剂对照试验。

Ursolic acid has no additional effect on muscle strength and mass in active men undergoing a high-protein diet and resistance training: A double-blind and placebo-controlled trial.

机构信息

Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goias, Goiânia, Brazil.

Faculty of Physical Education and Dance, Federal University of Goias, Goiânia, Brazil.

出版信息

Clin Nutr. 2021 Feb;40(2):581-589. doi: 10.1016/j.clnu.2020.06.004. Epub 2020 Jun 13.

DOI:10.1016/j.clnu.2020.06.004

PMID:32593524

Abstract

BACKGROUND

Ursolic acid (UA) is thought to have an anabolic effect on muscle mass in humans. This study sought to compare the effects of UA and a placebo on muscle strength and mass in young men undergoing resistance training (RT) and consuming a high-protein diet.

METHODS

A clinical, double-blind, placebo-controlled trial was conducted for 8 weeks. The Control + RT group (CON n = 12) received 400 mg/d of placebo, and the UA + RT group (UA n = 10) received 400 mg/d of UA. Both groups ingested ~1.6 g/kg of protein and performed the same RT program. Pre- and post-intervention, both groups were evaluated for anthropometric measures, body composition, food intake and muscle strength.

RESULTS

Food intake remained unchanged throughout the study. Both groups showed significant increases in body weight (CON Δ: 2.12 ± 0.47 kg, p = 0.001 vs. UA Δ: 2.24 ± 0.67 kg, p = 0.009), body mass index (BMI) (CON Δ: 0.69 ± 0.15 kg/m, p = 0.001 vs. UA Δ: 0.75 ± 0.23, p = 0.011) and thigh circumference (CON Δ: 1.50 ± 0.36, p = 0.002 vs. UA Δ: 2.46 ± 0.50 cm, p = 0.003 vs. UA 1.84 ± 0.82 cm, p = 0.001), with differences between them. There was no difference in the arm, waist and hip circumferences. Both groups showed increases in muscle mass (CON Δ: 1.12 ± 0.26, p = 0.001 vs. UA Δ: 1.08 ± 0.28 kg, p = 0.004), but there was no significant difference between them. Additionally, there were significant increases in the one repetition maximum test in the bench press and in the 10-repetition maximum test in the knee extension (CON Δ: 5.00 ± 2.09, p = 0.036 vs. UA Δ: 7.8 ± 1.87, p = 0.340 and CON Δ: 3.58 ± 1.15, p = 0.010 vs. UA Δ: 1.20 ± 0.72, p = 0.133), respectively, with no difference between them.

CONCLUSIONS

Ursolic acid had no synergic effect on muscle strength and mass in response to RT in physically active men consuming a high-protein diet.

BRAZILIAN CLINICAL TRIALS REGISTRY (REBEC): RBR-76tbqs.

摘要

背景

熊果酸（UA）被认为对人类的肌肉质量具有合成代谢作用。本研究旨在比较 UA 和安慰剂对进行抗阻训练（RT）并摄入高蛋白饮食的年轻男性的肌肉力量和质量的影响。

方法

进行了为期 8 周的临床、双盲、安慰剂对照试验。对照组+RT 组（CON n=12）接受 400mg/d 的安慰剂，熊果酸+RT 组（UA n=10）接受 400mg/d 的 UA。两组均摄入约 1.6g/kg 的蛋白质，并进行相同的 RT 计划。干预前后，两组均进行人体测量学指标、身体成分、食物摄入量和肌肉力量评估。

结果

研究期间食物摄入量保持不变。两组体重均显著增加（CON Δ：2.12±0.47kg，p=0.001 vs. UA Δ：2.24±0.67kg，p=0.009），体重指数（BMI）（CON Δ：0.69±0.15kg/m，p=0.001 vs. UA Δ：0.75±0.23，p=0.011）和大腿围（CON Δ：1.50±0.36cm，p=0.002 vs. UA Δ：2.46±0.50cm，p=0.003 vs. UA 1.84±0.82cm，p=0.001），两组之间存在差异。手臂、腰部和臀部周长没有差异。两组肌肉质量均增加（CON Δ：1.12±0.26kg，p=0.001 vs. UA Δ：1.08±0.28kg，p=0.004），但无显著差异。此外，仰卧推举的 1 次重复最大测试和腿伸展的 10 次重复最大测试的力量都显著增加（CON Δ：5.00±2.09，p=0.036 vs. UA Δ：7.8±1.87，p=0.340 和 CON Δ：3.58±1.15，p=0.010 vs. UA Δ：1.20±0.72，p=0.133），但两组之间无差异。