State Key Laboratory of Cognitive Neuroscience and Learning , Beijing Normal University, Beijing, China; Jiangsu Provincial Key Laboratory of Special Children's Impairment and Intervention, Nanjing Normal University of Special Education, Nanjing, China.
College of Educational Science, Anhui Normal University, Wuhu, Anhui, China.
J Clin Neurosci. 2020 Aug;78:327-332. doi: 10.1016/j.jocn.2020.03.049. Epub 2020 Apr 13.
Using magnetic resonance imaging to determine neuropathology in autism spectrum disorders, we report findings on the volume of the amygdala and hippocampus in autistic children. The volumes of amygdala, hippocampus and total brain were obtained by volbrain and their volumes were measured in young people (6.5-27.0 years of age) that comes from ABIDE dataset. Although there was no significant difference in total brain capacity between groups, autistic children (6.5-12.0 years of age) had larger right and left absolute and relative amygdala volumes than the control group. There was no difference in amygdala volume between adolescence (13-19 years old) and adults (20-27 years old). Interestingly, the volume of the amygdala in typical developing children increased significantly from 6.5 to 27 years of age. Thus, amygdala in children with autism was initially small, but no age-related increases were observed in normal developing children. The right absolute hippocampal volume of autistic patients was also larger than that of normal adults, but not after controlling the total brain volume. These cross-sectional findings suggest that abnormal patterns of hippocampal and amygdala development continue into adolescence in autistic patients.
我们使用磁共振成像来确定自闭症谱系障碍中的神经病理学，报告了自闭症儿童杏仁核和海马体体积的研究结果。使用 volbrain 获得杏仁核、海马体和全脑的体积，并在来自 ABIDE 数据集的年轻人（6.5-27.0 岁）中测量其体积。尽管两组之间的总脑容量没有显著差异，但自闭症儿童（6.5-12.0 岁）的右侧和左侧杏仁核绝对和相对体积大于对照组。在青春期（13-19 岁）和成年期（20-27 岁）之间，杏仁核体积没有差异。有趣的是，典型发育儿童的杏仁核体积从 6.5 岁到 27 岁显著增加。因此，自闭症儿童的杏仁核最初较小，但在正常发育儿童中未观察到与年龄相关的增加。自闭症患者的右绝对海马体体积也大于正常成年人，但在控制总脑容量后则不然。这些横断面研究结果表明，自闭症患者的海马体和杏仁核发育异常模式一直持续到青春期。
