自闭症谱系障碍中海马神经发生的研究进展
Research progress on hippocampal neurogenesis in autism spectrum disorder.
作者信息
Chen Mengxiang, Guo Lanmin, Li Qinghong, Yang Shunbo, Li Wei, Lai Yanmei, Lv Zhihai
机构信息
Department of Pediatric Rehabilitation Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College) Guangdong China.
Department of Child Health The Third Affiliated Hospital of Jiamusi University Heilongjiang China.
出版信息
Pediatr Investig. 2024 Jul 23;8(3):215-223. doi: 10.1002/ped4.12440. eCollection 2024 Sep.
Abstract
Autism spectrum disorder (ASD) is a group of severe neurodevelopmental disorders with unclear etiology and significant heterogeneity that is emerging as a global public health concern. Increasing research suggests the involvement of hippocampal neurogenesis defects in the onset and development of ASD, drawing increasing amounts of attention to hippocampal neurogenesis issues in ASD. In this paper, we analyze relevant international studies on hippocampal neurogenesis in ASD, discuss the role of neurobiology in the pathogenesis of ASD, and explore the potential of improving hippocampal neurogenesis as a therapeutic approach for ASD. This review aims to provide new treatment perspectives and theoretical foundations for clinical practice.
摘要
自闭症谱系障碍（ASD）是一组病因不明且具有显著异质性的严重神经发育障碍，正日益成为全球公共卫生问题。越来越多的研究表明，海马神经发生缺陷与ASD的发病和发展有关，这使得ASD中的海马神经发生问题受到越来越多的关注。在本文中，我们分析了关于ASD中海马神经发生的相关国际研究，讨论了神经生物学在ASD发病机制中的作用，并探索了改善海马神经发生作为ASD治疗方法的潜力。本综述旨在为临床实践提供新的治疗视角和理论基础。
相似文献
1
Research progress on hippocampal neurogenesis in autism spectrum disorder.自闭症谱系障碍中海马神经发生的研究进展
Pediatr Investig. 2024 Jul 23;8(3):215-223. doi: 10.1002/ped4.12440. eCollection 2024 Sep.
2
Implication of Hippocampal Neurogenesis in Autism Spectrum Disorder: Pathogenesis and Therapeutic Implications.海马神经发生在自闭症谱系障碍中的意义：发病机制和治疗意义。
Curr Neuropharmacol. 2023;21(11):2266-2282. doi: 10.2174/1570159X21666221220155455.
3
The Liver X Receptor Agonist TO901317 Ameliorates Behavioral Deficits in Two Mouse Models of Autism.肝脏X受体激动剂TO901317改善两种自闭症小鼠模型的行为缺陷。
Front Cell Neurosci. 2019 May 14;13:213. doi: 10.3389/fncel.2019.00213. eCollection 2019.
4
Neonatal curcumin treatment restores hippocampal neurogenesis and improves autism-related behaviors in a mouse model of autism.姜黄素处理新生鼠可恢复自闭症模型鼠海马神经发生并改善自闭症相关行为。
Psychopharmacology (Berl). 2020 Dec;237(12):3539-3552. doi: 10.1007/s00213-020-05634-5. Epub 2020 Aug 15.
5
Criss-crossing autism spectrum disorder and adult neurogenesis.自闭症谱系障碍与成人神经发生的交叉研究。
J Neurochem. 2021 Nov;159(3):452-478. doi: 10.1111/jnc.15501. Epub 2021 Sep 20.
6
The Gene Dose-Dependently Controls Hippocampal Neurogenesis and the Expression of Autism-Like Behaviors.该基因剂量依赖性地控制海马神经发生和自闭症样行为的表达。
J Neurosci. 2024 Jan 31;44(5):e1058232023. doi: 10.1523/JNEUROSCI.1058-23.2023.
7
Hippocampal contributions to social and cognitive deficits in autism spectrum disorder.海马对自闭症谱系障碍的社交和认知缺陷的贡献。
Trends Neurosci. 2021 Oct;44(10):793-807. doi: 10.1016/j.tins.2021.08.005. Epub 2021 Sep 11.
8
Comprehensive immunoprofiling of neurodevelopmental disorders suggests three distinct classes based on increased neurogenesis, Th-1 polarization or IL-1 signaling.神经发育障碍的综合免疫分析表明，基于神经发生增加、Th1 极化或 IL-1 信号传导的三种不同类型。
Brain Behav Immun. 2024 Jan;115:505-516. doi: 10.1016/j.bbi.2023.11.013. Epub 2023 Nov 14.
9
Human amniotic epithelial cell transplantation promotes neurogenesis and ameliorates social deficits in BTBR mice.人羊膜上皮细胞移植促进神经发生并改善 BTBR 小鼠的社交缺陷。
Stem Cell Res Ther. 2019 May 31;10(1):153. doi: 10.1186/s13287-019-1267-0.
10
Developmental exposure to diesel exhaust upregulates transcription factor expression, decreases hippocampal neurogenesis, and alters cortical lamina organization: relevance to neurodevelopmental disorders.发育过程中接触柴油机废气会上调转录因子表达，减少海马神经发生，并改变皮质层结构：与神经发育障碍相关。
J Neurodev Disord. 2020 Dec 16;12(1):41. doi: 10.1186/s11689-020-09340-3.
引用本文的文献
1
NEXMIF overexpression is associated with autism-like behaviors and alterations in dendritic arborization and spine formation in mice.NEXMIF过表达与小鼠的自闭症样行为以及树突分支和棘突形成的改变有关。
Front Neurosci. 2025 Jun 18;19:1556570. doi: 10.3389/fnins.2025.1556570. eCollection 2025.
2
Survey of transcriptome analyses of hippocampal neurogenesis with focus on adult dentate gyrus stem cells.聚焦成年齿状回干细胞的海马神经发生转录组分析综述
Front Cell Dev Biol. 2025 May 30;13:1605116. doi: 10.3389/fcell.2025.1605116. eCollection 2025.
3
Disclosing the Complexities of Childhood Neurodevelopmental Disorders.揭示儿童神经发育障碍的复杂性。
Children (Basel). 2024 Dec 25;12(1):16. doi: 10.3390/children12010016.
4
Adult neurogenesis in the ventral hippocampus decreased among animal models of neurodevelopmental disorders.在神经发育障碍的动物模型中，腹侧海马体中的成年神经发生减少。
Front Neural Circuits. 2024 Dec 23;18:1504191. doi: 10.3389/fncir.2024.1504191. eCollection 2024.
本文引用的文献
1
RETRACTED ARTICLE: Wnt, notch signaling and exercise: what are their functions?撤回文章：Wnt、Notch信号通路与运动：它们的功能是什么？
Hum Cell. 2024 Sep;37(5):1612. doi: 10.1007/s13577-024-01036-3. Epub 2024 Feb 22.
2
Deep-Learning-Based Analysis Reveals a Social Behavior Deficit in Mice Exposed Prenatally to Nicotine.基于深度学习的分析揭示了产前暴露于尼古丁的小鼠存在社交行为缺陷。
Cells. 2024 Feb 1;13(3):275. doi: 10.3390/cells13030275.
3
CCN3/NOV Regulates Proliferation and Neuronal Differentiation in Mouse Hippocampal Neural Stem Cells via the Activation of the Notch/PTEN/AKT Pathway.CCN3/NOV 通过激活 Notch/PTEN/AKT 通路调节小鼠海马神经干细胞的增殖和神经元分化。
Int J Mol Sci. 2023 Jun 19;24(12):10324. doi: 10.3390/ijms241210324.
4
Reduced grey matter volume of amygdala and hippocampus is associated with the severity of autistic symptoms and language abilities in school-aged children with Autism Spectrum Disorder: an exploratory study.杏仁核和海马体灰质体积减少与自闭症谱系障碍学龄儿童自闭症症状严重程度和语言能力相关：一项探索性研究。
Brain Struct Funct. 2023 Jul;228(6):1573-1579. doi: 10.1007/s00429-023-02660-9. Epub 2023 Jun 11.
5
Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2020.2020 年，美国 11 个监测点自闭症和发育障碍监测网络 8 岁儿童自闭症谱系障碍的流行率和特征。
MMWR Surveill Summ. 2023 Mar 24;72(2):1-14. doi: 10.15585/mmwr.ss7202a1.
6
Zinc Water Prevents Autism-Like Behaviors in the BTBR Mice.锌水可预防 BTBR 小鼠的自闭症样行为。
Biol Trace Elem Res. 2023 Oct;201(10):4779-4792. doi: 10.1007/s12011-022-03548-1. Epub 2023 Jan 5.
7
Adult hippocampal neurogenesis and social behavioural deficits in the R451C Neuroligin3 mouse model of autism are reverted by the antidepressant fluoxetine.在自闭症的R451C神经连接蛋白3小鼠模型中，成年海马体神经发生及社交行为缺陷可通过抗抑郁药氟西汀得到改善。
J Neurochem. 2023 May;165(3):318-333. doi: 10.1111/jnc.15753. Epub 2023 Jan 9.
8
Implication of Hippocampal Neurogenesis in Autism Spectrum Disorder: Pathogenesis and Therapeutic Implications.海马神经发生在自闭症谱系障碍中的意义：发病机制和治疗意义。
Curr Neuropharmacol. 2023;21(11):2266-2282. doi: 10.2174/1570159X21666221220155455.
9
Inflammation and Autophagy: A Convergent Point between Autism Spectrum Disorder (ASD)-Related Genetic and Environmental Factors: Focus on Aluminum Adjuvants.炎症与自噬：自闭症谱系障碍（ASD）相关遗传和环境因素的交汇点：聚焦铝佐剂
Toxics. 2022 Aug 31;10(9):518. doi: 10.3390/toxics10090518.
10
Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis.自闭症相关染色质重塑因子 CHD8 在胚胎和成年大脑神经发生中的保守和独特功能。
J Neurosci. 2022 Nov 2;42(44):8373-8392. doi: 10.1523/JNEUROSCI.2400-21.2022. Epub 2022 Sep 20.
Zotero 插件