Chen Mengxiang, Guo Lanmin, Li Qinghong, Yang Shunbo, Li Wei, Lai Yanmei, Lv Zhihai
Department of Pediatric Rehabilitation Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College) Guangdong China.
Department of Child Health The Third Affiliated Hospital of Jiamusi University Heilongjiang China.
Pediatr Investig. 2024 Jul 23;8(3):215-223. doi: 10.1002/ped4.12440. eCollection 2024 Sep.
Autism spectrum disorder (ASD) is a group of severe neurodevelopmental disorders with unclear etiology and significant heterogeneity that is emerging as a global public health concern. Increasing research suggests the involvement of hippocampal neurogenesis defects in the onset and development of ASD, drawing increasing amounts of attention to hippocampal neurogenesis issues in ASD. In this paper, we analyze relevant international studies on hippocampal neurogenesis in ASD, discuss the role of neurobiology in the pathogenesis of ASD, and explore the potential of improving hippocampal neurogenesis as a therapeutic approach for ASD. This review aims to provide new treatment perspectives and theoretical foundations for clinical practice.
自闭症谱系障碍（ASD）是一组病因不明且具有显著异质性的严重神经发育障碍，正日益成为全球公共卫生问题。越来越多的研究表明，海马神经发生缺陷与ASD的发病和发展有关，这使得ASD中的海马神经发生问题受到越来越多的关注。在本文中，我们分析了关于ASD中海马神经发生的相关国际研究，讨论了神经生物学在ASD发病机制中的作用，并探索了改善海马神经发生作为ASD治疗方法的潜力。本综述旨在为临床实践提供新的治疗视角和理论基础。
