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Whole-brain three-dimensional imaging for quantification of drug targets and treatment effects in mouse models of neurodegenerative diseases.

作者信息

Hansen Henrik H, Roostalu Urmas, Hecksher-Sørensen Jacob

机构信息

Gubra, Hørsholm, Denmark.

出版信息

Neural Regen Res. 2020 Dec;15(12):2255-2257. doi: 10.4103/1673-5374.284983.

DOI:10.4103/1673-5374.284983
PMID:32594044
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7749470/
Abstract
摘要

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3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice.3D 映射揭示了小鼠中特定于网络的淀粉样蛋白进展和皮质下易感性。
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Regional vulnerability and spreading of hyperphosphorylated tau in seeded mouse brain.在接种的小鼠脑中,磷酸化tau 的区域性易损性和扩散。
Neurobiol Dis. 2019 Jul;127:398-409. doi: 10.1016/j.nbd.2019.03.010. Epub 2019 Mar 14.
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Whole-Brain Analysis of Cells and Circuits by Tissue Clearing and Light-Sheet Microscopy.基于组织透明化和光片显微镜的全脑细胞和回路分析
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