López-Mora Diego Alfonso, Lagos Luis Alarcón, Estorch Montserrat, Carrio Ignasi
Nuclear Medicine Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Nuclear Medicine Department, Hospital Dr. Gustavo Fricke, Viña del Mar, Valparaíso, Chile.
Recent Results Cancer Res. 2020;216:905-918. doi: 10.1007/978-3-030-42618-7_30.
During the last decade, positron emission tomography/computed tomography (PET/CT) and single-photon emission computed tomography/computed tomography (SPECT/CT) have procured advances in research and clinical application of fusion imaging. The recent introduction of digital PET/CT opens new horizons for multimodality molecular imaging. This system offers more precise, simultaneous morphologic, functional, and molecular information of a living system. Moreover, other combinations of anatomic and functional imaging modalities hold promise in basic medical research or in clinical medicine. These developments are paralleled by advances in the field of biomolecules and particles that will provide new agents useful for more than one imaging modality and will facilitate the study of the same target by different imaging devices. Digital PET/CT may emerge as a powerful multimodality technique with great clinical impact on the diagnosis and therapy assessment of oncological diseases due to its enhanced sensitivity.
在过去十年中，正电子发射断层扫描/计算机断层扫描（PET/CT）和单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）推动了融合成像在研究和临床应用方面的进展。数字PET/CT的最新推出为多模态分子成像开辟了新视野。该系统能提供关于活体系统更精确、同步的形态、功能和分子信息。此外，解剖学和功能成像模态的其他组合在基础医学研究或临床医学中也具有前景。这些进展与生物分子和粒子领域的进步并行，后者将提供对不止一种成像模态有用的新型试剂，并有助于通过不同成像设备对同一靶点进行研究。由于其更高的灵敏度，数字PET/CT可能会成为一种对肿瘤疾病的诊断和治疗评估具有重大临床影响的强大多模态技术。
