Faculty of Veterinary Medicine, Department of Biochemistry, Van Yuzuncu Yil University, Van, Turkey.
Faculty of Veterinary Medicine, Department of Biochemistry, Siirt University, Siirt, Turkey.
Arch Physiol Biochem. 2022 Dec;128(6):1539-1547. doi: 10.1080/13813455.2020.1781900. Epub 2020 Jun 27.
The effect of evening primrose oil on adiponectin level and some biochemical parameters in model of fructose-induced metabolic syndrome were investigated. The rats were divided into 4 groups: control, evening primrose oil, fructose, fructose + evening primrose oil. Body weight, daily feed and water consumptions and systolic blood pressures of animals were measured. At the end of trial, blood samples were taken, livers were excised and histopathological examination was performed. Glucose, uric acid, triglyceride, T.cholesterol, LDL, HDL, VLDL, ALT, AST, ALP, LDH, adiponectin, insulin, IL-6, TNF-α, TAC, and TOS levels were analysed. Some analysed parameters and systolic blood pressure of fructose + evening primrose oil group decreased significantly compared to fructose group and adiponectin, TAC, and HDL levels were significantly increased. As conclusion, evening primrose oil can be considered as antioxidant agent by reducing oxidative stress, increasing adiponectin levels and insulin sensitivity, anti-inflammatory properties, exhibiting anti-atherogenic effect by regulating dyslipidemia and systolic blood pressure.
研究了月见草油对果糖诱导的代谢综合征模型中脂联素水平和一些生化参数的影响。将大鼠分为 4 组：对照组、月见草油组、果糖组、果糖+月见草油组。测量动物的体重、每日饲料和水的消耗以及收缩压。试验结束时，采集血液样本，切除肝脏并进行组织病理学检查。分析血糖、尿酸、甘油三酯、总胆固醇、LDL、HDL、VLDL、ALT、AST、ALP、LDH、脂联素、胰岛素、IL-6、TNF-α、TAC 和 TOS 水平。与果糖组相比，果糖+月见草油组的一些分析参数和收缩压显著降低，脂联素、TAC 和 HDL 水平显著升高。因此，月见草油可以通过降低氧化应激、增加脂联素水平和胰岛素敏感性、抗炎特性、通过调节血脂异常和收缩压来发挥抗动脉粥样硬化作用，被认为是一种抗氧化剂。
