三萜类化合物对肺纤维化的防治作用。

College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.

The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China.

Molecules. 2022 Jul 29;27(15):4870. doi: 10.3390/molecules27154870.

Five new triterpenoids, oenotheralanosterols C-G (-), with seven known triterpenoidcompounds, namely 2,3,19-trihydroxy-24-norurs4,12-dien-28-oic acid (), 3,23-dihydroxy-1-oxo-olean-12-en-28-oic acid (), remangilone C (), knoxivalic acid A (), termichebulolide (), rosasecotriterpene A (), androsanortriterpene C (), were extracted and separated from the dichloromethane part of L. The anti-pulmonary fibrosis activities of all the compounds against TGF-1-induced damage tonormal human lung epithelial (BEAS-2B) cells were investigated in vitro. The results showed that compounds , , , and exhibited significant anti-pulmonary fibrosis activities, with EC values ranging from 4.7 μM to 9.9 μM.

从中提取并分离得到了五个新的三萜类化合物，oenotheralanosterols C-G (-)，以及七个已知的三萜类化合物，分别是 2,3,19-三羟基-24-降乌苏 4,12-二烯-28-酸 ()、3,23-二羟基-1-氧代-齐墩-12-烯-28-酸 ()、remangilone C ()、knoxivalic 酸 A ()、termichebulolide ()、rosasecotriterpene A () 和 androsanortriterpene C ()。所有化合物对 TGF-β1 诱导的正常人类肺上皮细胞 (BEAS-2B) 损伤的体外抗肺纤维化活性进行了研究。结果表明，化合物、、、表现出显著的抗肺纤维化活性，EC 值范围为 4.7 μM 至 9.9 μM。