Tomar R S, Blakley B R, DeCoteau W E
Department of Veterinary Physiological Sciences, University of Saskatchewan, Saskatoon, Canada.
Int J Immunopharmacol. 1988;10(2):145-51. doi: 10.1016/0192-0561(88)90089-6.
The effects of T-2 toxin on the antibody producing ability of CD-1 mice after dietary exposure to 0, 2.5, 5 and 15 ppm of T-2 toxin for 29 days was studied. The antibody response against sheep red blood cells, a T-lymphocyte and macrophage-dependent response was suppressed at 2.5, 5 and 15 ppm of T-2 toxin exposure. In contrast, the antibody responses against dinitrophenyl-aminoethylcarbamylmethyl - Ficoll (DNP - Ficoll), a T-lymphocyte independent macrophage-dependent response, and Escherichia coli 0127 (LPS), a T-lymphocyte and macrophage-independent response, were not affected. These results suggest that the inhibitory effects of T-2 toxin on antibody-producing ability after subacute dietary exposure appear to be a direct affect on T-lymphocyte function, possibly involving the T-helper lymphocytes.
研究了CD-1小鼠在饮食中分别暴露于0、2.5、5和15 ppm的T-2毒素29天后，T-2毒素对其抗体产生能力的影响。针对绵羊红细胞的抗体反应，一种T淋巴细胞和巨噬细胞依赖性反应，在暴露于2.5、5和15 ppm的T-2毒素时受到抑制。相比之下，针对二硝基苯基-氨乙基氨基甲酰甲基-菲可（DNP-菲可）的抗体反应，一种T淋巴细胞非依赖性巨噬细胞依赖性反应，以及针对大肠杆菌0127（LPS）的抗体反应，一种T淋巴细胞和巨噬细胞非依赖性反应，均未受到影响。这些结果表明，亚急性饮食暴露后T-2毒素对抗体产生能力的抑制作用似乎是对T淋巴细胞功能的直接影响，可能涉及辅助性T淋巴细胞。
