Chakraborty Surajit, Basu Anirban
National Brain Research Centre, Manesar, Gurugram, Haryana, India.
F1000Res. 2020 Jun 23;9. doi: 10.12688/f1000research.24963.1. eCollection 2020.
Infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which belongs to the Coronaviridae family and is a positive-sense single-stranded RNA virus originating from Wuhan, China, was declared a global public health emergency on 11 March 2020. SARS-CoV-2 infection in humans is characterized by symptoms such as fever and dyspnea accompanied by infrequent incidence of lymphopenia, gastrointestinal complications such as elevated hepatic aminotransferases, and diarrhea. Originating in bats, the SARS-CoV-2 virus has been transmitted to humans likely via an intermediate host that is yet to be discovered. Owing to the absence of any vaccines or definite anti-viral drugs alongside the greater mobility of people across the globe, international and national efforts in containing and treating SARS-CoV-2 infection are experiencing severe difficulties. In this review, we have provided a picture of SARS-CoV-2 epidemiological characteristics, the clinical symptoms experienced by patients of varying age groups, the molecular virology of SARS-CoV-2, and the treatment regimens currently employed for fighting SARS-CoV-2 infection as well as their outcomes.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的感染于2020年3月11日被宣布为全球突发公共卫生事件。该病毒属于冠状病毒科，是一种源自中国武汉的正链单股RNA病毒。人类感染SARS-CoV-2的特征症状包括发热、呼吸困难，伴有淋巴细胞减少症的发生率较低、胃肠道并发症，如肝转氨酶升高和腹泻。SARS-CoV-2病毒起源于蝙蝠，可能通过尚未发现的中间宿主传播给人类。由于缺乏任何疫苗或确切的抗病毒药物，再加上全球人员流动性更大，国际和国家在控制和治疗SARS-CoV-2感染方面的努力正面临严重困难。在这篇综述中，我们呈现了SARS-CoV-2的流行病学特征、不同年龄组患者经历的临床症状、SARS-CoV-2的分子病毒学，以及目前用于对抗SARS-CoV-2感染的治疗方案及其结果。
