微小 RNA 在对比剂诱导肾病中的作用：系统评价和荟萃分析。
The Role of MicroRNA in Contrast-Induced Nephropathy: A Scoping Review and Meta-Analysis.
机构信息
Department of Cardiology and Vascular Medicine, Mohammad Hoesin General Hospital, Palembang, Sumatera Selatan, Indonesia.
Biomedicine Doctoral Programme, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Sardjito General Hospital, Yogyakarta, Indonesia.
出版信息
Biomed Res Int. 2020 May 21;2020:4189621. doi: 10.1155/2020/4189621. eCollection 2020.
OBJECTIVE
Early diagnosis of contrast-induced nephropathy (CIN) remains crucial for successful treatment; unfortunately, the widely used serum creatinine is elevated only in the late stage of CIN. The circulating microRNAs (miRNAs) are stable biomarker that might be useful. The aim of this scoping review and meta-analysis is to assess the role of miRNAs in CIN.
METHODS
We performed a systematic literature search on topics that assess the role of miRNAs in CIN from several electronic databases.
RESULTS
There were 6 preclinical studies and 2 of them validated their findings in human. Only miR-30a, miR-30c, miR-30e, and miR-188 have been validated in human models. Meta-analysis showed that increase in miR-30a expression was associated with higher incidence of CIN (OR 4.48 [1.52, 13.26], = 0.007; : 94%, < 0.001). An increase in miR-30e expression was associated with higher incidence of CIN (OR 2.34 [1.70, 3.20], < 0.001; : 0%, = 0.76). There is an indication that miR-188 is associated with contrast-induced apoptosis and might potentially be a drug target in the future.
CONCLUSION
This study highlighted the importance of certain miRNAs in CIN pathophysiology. Future researches should explore on the prognostic and therapeutic implication of miRNA in CIN.
目的
对比剂诱导肾病（CIN）的早期诊断仍然至关重要；不幸的是，广泛使用的血清肌酐在 CIN 的晚期才会升高。循环 microRNAs（miRNAs）是一种稳定的生物标志物，可能具有重要作用。本 scoping 综述和荟萃分析旨在评估 miRNAs 在 CIN 中的作用。
方法
我们从多个电子数据库中对评估 miRNAs 在 CIN 中作用的主题进行了系统的文献检索。
结果
共有 6 项临床前研究，其中 2 项在人体中验证了他们的发现。只有 miR-30a、miR-30c、miR-30e 和 miR-188 在人体模型中得到了验证。荟萃分析显示，miR-30a 表达增加与 CIN 发生率升高相关（OR 4.48 [1.52, 13.26]， = 0.007； = 94%， < 0.001）。miR-30e 表达增加与 CIN 发生率升高相关（OR 2.34 [1.70, 3.20]， < 0.001； = 0%， = 0.76）。有迹象表明 miR-188 与对比剂诱导的细胞凋亡有关，将来可能成为药物治疗的靶点。
结论
本研究强调了某些 miRNAs 在 CIN 病理生理学中的重要性。未来的研究应探讨 miRNA 在 CIN 中的预后和治疗意义。
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