Tang Shuang, Ma Yun-Bao, Geng Chang-An, Shen Cheng, Li Tian-Ze, Zhang Xue-Mei, Su Li-Hua, Gao Zhen, Hu Jing, Chen Ji-Jun
State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Nat Prod Bioprospect. 2020 Aug;10(4):251-260. doi: 10.1007/s13659-020-00255-z. Epub 2020 Jun 28.
Four new sesquiterpenoids, artemyrianins A-D (1-4), and three new norlignans, artemyrianins E-G (5-7), together with five known compounds (8-12), were isolated from the aerial parts of Artemisia myriantha (Asteraceae). The new compounds were established by spectroscopic data analyses (HRMS, IR, 1D and 2D NMR), and their absolute configurations were confirmed by the single-crystal X-ray diffraction or ECD calculations. The isolates showed cytotoxicity against HepG2 cells with IC values ranging from 33.3 to 145.2 μM.
从多花蒿（菊科）地上部分分离得到4个新的倍半萜类化合物——青蒿蜜环素A-D（1-4）、3个新的去甲木脂素类化合物——青蒿蜜环素E-G（5-7），以及5个已知化合物（8-12）。通过光谱数据分析（高分辨质谱、红外光谱、一维和二维核磁共振谱）确定了新化合物的结构，并通过单晶X射线衍射或电子圆二色计算确定了它们的绝对构型。这些分离得到的化合物对肝癌细胞HepG2显示出细胞毒性，半数抑制浓度值范围为33.3至145.2 μM。
