青蒿素A-J，来自多花蒿的具有细胞毒性的吉马烷型倍半萜内酯。
Artemyrianosins A-J, cytotoxic germacrane-type sesquiterpene lactones from Artemisia myriantha.
作者信息
Zhang Xin, Ma Yun-Bao, He Xiao-Feng, Li Tian-Ze, Geng Chang-An, Su Li-Hua, Tang Shuang, Gao Zhen, Chen Ji-Jun
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, 132# Lanhei Road, Kunming, 650201, Yunnan, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
出版信息
Nat Prod Bioprospect. 2022 May 2;12(1):16. doi: 10.1007/s13659-022-00340-5.
Ten new germacrane-type sesquiterpenoids, artemyrianosins A-J (1-10), were isolated from the aerial parts of Artemisia myriantha. Their structures were elucidated by spectral analyses including UV, IR, HRESIMS, 1D and 2D NMR, ECD and the absolute configurations of compounds 1 and 7-9 were characterized using X-ray crystallography. All isolates were tested their cytotoxicity against three human hepatoma cell lines (HepG2, Huh7, and SK-Hep-1), and compounds 1-3, 7, and 10 showed cytotoxicity with IC values ranging from 43.7 to 89.3 μM. Among them, the most active compound 3 exhibited activity against three human hepatoma cell lines with IC values of 43.7 μM (HepG2), 47.9 μM (Huh7), and 44.9 μM (SK-Hep-1).
从多花蒿的地上部分分离出10种新的吉马烷型倍半萜，即青蒿米里烷素A - J（1 - 10）。通过包括紫外、红外、高分辨电喷雾电离质谱、一维和二维核磁共振、电子圆二色光谱等光谱分析对其结构进行了阐明，化合物1以及7 - 9的绝对构型通过X射线晶体学进行了表征。对所有分离物进行了针对三种人肝癌细胞系（HepG2、Huh7和SK - Hep - 1）的细胞毒性测试，化合物1 - 3、7和10表现出细胞毒性，IC值范围为43.7至89.3 μM。其中，活性最强的化合物3对三种人肝癌细胞系均有活性，IC值分别为43.7 μM（HepG2）、47.9 μM（Huh7）和44.9 μM（SK - Hep - 1）。
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