Gilman S, Markel D S, Koeppe R A, Junck L, Kluin K J, Gebarski S S, Hichwa R D
Department of Neurology, University of Michigan, Ann Arbor 48109-0316.
Ann Neurol. 1988 Mar;23(3):223-30. doi: 10.1002/ana.410230303.
We studied local cerebral metabolic rates for glucose (1CMRglc) with 18F-2-fluoro-2-deoxy-D-glucose and positron emission tomography (PET) in 30 patients with olivopontocerebellar atrophy (OPCA) and 30 age-matched control subjects without neurological disease. The diagnosis of OPCA was based on the history and physical findings and on the exclusion of other causes of cerebellar ataxia by means of laboratory investigations. Computed tomographic scans revealed some degree of atrophy of the cerebellum in most patients with OPCA, and many also had atrophy of the brainstem. PET studies in these patients revealed significant hypometabolism in the cerebellar hemispheres, cerebellar vermis, and brainstem in comparison with the normal control subjects. A significant relationship was found between the degree of atrophy and the level of 1CMRglc in the cerebellum and brainstem. Nevertheless, several patients had minimal atrophy and substantially reduced 1CMRglc, suggesting that atrophy does not fully account for the finding of hypometabolism. 1CMRglc was within normal limits for the thalamus and cerebral cortex. The data suggest that PET/1CMRglc may be useful as a diagnostic test in patients with the adult onset of cerebellar ataxia.
我们使用18F - 2 - 氟 - 2 - 脱氧 - D - 葡萄糖和正电子发射断层扫描（PET）技术，对30例橄榄脑桥小脑萎缩（OPCA）患者及30名年龄匹配的无神经系统疾病的对照者进行了局部脑葡萄糖代谢率（1CMRglc）研究。OPCA的诊断基于病史、体格检查结果以及通过实验室检查排除小脑共济失调的其他病因。计算机断层扫描显示，大多数OPCA患者存在一定程度的小脑萎缩，许多患者还伴有脑干萎缩。与正常对照者相比，这些患者的PET研究显示小脑半球、小脑蚓部和脑干存在明显的代谢减低。小脑和脑干的萎缩程度与1CMRglc水平之间存在显著相关性。然而，有几名患者萎缩程度轻微，但1CMRglc却大幅降低，这表明萎缩并不能完全解释代谢减低这一现象。丘脑和大脑皮质的1CMRglc在正常范围内。这些数据表明，PET/1CMRglc可能作为成人起病的小脑共济失调患者的一种诊断检查方法。
