Vlasova A V, Isakov V A, Pilipenko V I, Sheveleva S A, Markova Y M, Polyanina A S, Maev I V
Federal Research Centre of Nutrition, Biotechnology and Food Safety.
Yevdokimov Moscow State University of Medicine and Dentistry.
Ter Arkh. 2019 Aug 15;91(8):47-51. doi: 10.26442/00403660.2019.08.000383.
To assess the role of Methanobrevibacter smithii in patients with irritable bowel syndrome associated with small intestinal bowel overgrowth.
Sixty - seven patients with IBS according to Rome IV were enrolled into the study in whom hydrogen breath test was performed. Thirty - two healthy subjects with negative breath test was used as a control. All IBS symptoms assessed daily with 5 grade Lykert scale for 7 days, stool was assessed by Brystol stool scale. M. smithii was confirmed in stool samples by PCR.
In 67 IBS patients CH4 overproduction was found in 32 (47.7%), H2 overproduction in 31 (46.2%) and normal values in 4 (5.9%) by hydrogen breath test. M. smithii was confirmed by stool PCR in all patients with CH4 overproduction. Severity and prevalence of main clinical features of IBS were similar in both SIBO groups but were significantly higher than in control (p.
评估史氏甲烷短杆菌在伴有小肠细菌过度生长的肠易激综合征患者中的作用。
根据罗马IV标准纳入67例肠易激综合征患者并进行氢呼气试验。32例呼气试验阴性的健康受试者作为对照。所有肠易激综合征症状采用5级李克特量表连续7天每日评估，粪便采用布里斯托粪便量表评估。通过聚合酶链反应在粪便样本中确认史氏甲烷短杆菌。
通过氢呼气试验，67例肠易激综合征患者中，32例（47.7%）甲烷产生过多，31例（46.2%）氢气产生过多，4例（5.9%）值正常。所有甲烷产生过多的患者粪便聚合酶链反应均确认有史氏甲烷短杆菌。小肠细菌过度生长的两个亚组中肠易激综合征主要临床特征的严重程度和患病率相似，但均显著高于对照组（p.
