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本文引用的文献

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DNA vaccine protection against SARS-CoV-2 in rhesus macaques.DNA 疫苗对食蟹猴 SARS-CoV-2 的保护作用。
Science. 2020 Aug 14;369(6505):806-811. doi: 10.1126/science.abc6284. Epub 2020 May 20.
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Development of an inactivated vaccine candidate for SARS-CoV-2.SARS-CoV-2 灭活疫苗候选物的研发。
Science. 2020 Jul 3;369(6499):77-81. doi: 10.1126/science.abc1932. Epub 2020 May 6.
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The potential role of Th17 immune responses in coronavirus immunopathology and vaccine-induced immune enhancement.辅助 T 细胞 17 免疫应答在冠状病毒免疫病理学和疫苗诱导免疫增强中的潜在作用。
Microbes Infect. 2020 May-Jun;22(4-5):165-167. doi: 10.1016/j.micinf.2020.04.005. Epub 2020 Apr 17.
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Severe acute respiratory syndrome-associated coronavirus vaccines formulated with delta inulin adjuvants provide enhanced protection while ameliorating lung eosinophilic immunopathology.用δ-菊粉佐剂配制的严重急性呼吸综合征相关冠状病毒疫苗在改善肺部嗜酸性粒细胞免疫病理学的同时提供了增强的保护作用。
J Virol. 2015 Mar;89(6):2995-3007. doi: 10.1128/JVI.02980-14. Epub 2014 Dec 17.
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Effects of Toll-like receptor stimulation on eosinophilic infiltration in lungs of BALB/c mice immunized with UV-inactivated severe acute respiratory syndrome-related coronavirus vaccine.TLR 刺激对紫外线灭活 SARS-CoV 疫苗免疫 BALB/c 小鼠肺部嗜酸性粒细胞浸润的影响。
J Virol. 2014 Aug;88(15):8597-614. doi: 10.1128/JVI.00983-14. Epub 2014 May 21.
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Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus.接种 SARS 冠状病毒疫苗会导致在 SARS 病毒攻击时肺部免疫病理学发生。
PLoS One. 2012;7(4):e35421. doi: 10.1371/journal.pone.0035421. Epub 2012 Apr 20.
7
A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge.一种双灭活严重急性呼吸综合征冠状病毒疫苗在小鼠中提供不完全保护，并在挑战时诱导嗜酸性炎症性肺部反应增加。
J Virol. 2011 Dec;85(23):12201-15. doi: 10.1128/JVI.06048-11. Epub 2011 Sep 21.
8
Role of IL-23-Th17 cell axis in allergic airway inflammation.白细胞介素-23-辅助性T细胞17轴在过敏性气道炎症中的作用。
Int Arch Allergy Immunol. 2009;149 Suppl 1:108-12. doi: 10.1159/000211382. Epub 2009 Jun 3.
9
Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease.由于Toll样受体刺激不足导致的抗体亲和力成熟缺陷会加重呼吸道合胞病毒疾病。
Nat Med. 2009 Jan;15(1):34-41. doi: 10.1038/nm.1894. Epub 2008 Dec 14.
10
Receptor-binding domain of SARS-CoV spike protein induces long-term protective immunity in an animal model.严重急性呼吸综合征冠状病毒刺突蛋白的受体结合域在动物模型中诱导长期保护性免疫。
Vaccine. 2007 Apr 12;25(15):2832-8. doi: 10.1016/j.vaccine.2006.10.031. Epub 2006 Oct 30.

Coronavirus vaccine-associated lung immunopathology-what is the significance?

作者信息

Bottazzi Maria Elena, Strych Ulrich, Hotez Peter J, Corry David B

机构信息

Texas Children's Center for Vaccine Development, Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, USA; Department of Biology, Baylor University, USA.

Texas Children's Center for Vaccine Development, Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, USA.

出版信息

Microbes Infect. 2020 Oct;22(9):403-404. doi: 10.1016/j.micinf.2020.06.007. Epub 2020 Jun 26.

DOI:10.1016/j.micinf.2020.06.007
PMID:32599077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7318931/
Abstract
摘要