Grimaux M, Magdelenat H, Poisson M, Chamouard J M, Barritault D, Foncin J F, Philippon J
Laboratoire de Radiopathologie, Institut Curie, Paris.
Rev Neurol (Paris). 1988;144(2):96-103.
Epidermal growth factor receptor (EGF-R) were assayed by 125I-EGF binding in 28 surgical samples of human meningiomas. High affinity EGF-R were found in 26/28 tumors (92 p. 100) at concentrations ranging from 20 to 410 femtomoles per mg of membrane protein (fmol/mg prot. mb.). In 18/26 cases (64 p. 100), the EGF-R concentration was between 95 and 230 fmol/mg prot. mb. No relationship was found between the EGF-R level and the site or histopathology of the tumor. The only noticeable observations were the low levels of EGF-R in the 3 anaplasic meningiomas as compared to the whole population and the undetectable level of EGF-R in the angiomatous tumors. In addition, no correlation was found between EGF-R levels and the hormonal status of the patients, nor between EGF-R levels and the intratumoral concentration of progesterone receptors assayed simultaneously. The biological relevance of EGF-R in meningioma is discussed in this context.
采用¹²⁵I-表皮生长因子（EGF）结合法对28例人脑膜瘤手术标本中的表皮生长因子受体（EGF-R）进行检测。在28个肿瘤中的26个（92%）发现了高亲和力EGF-R，其浓度范围为每毫克膜蛋白20至410飞摩尔（fmol/mg prot. mb.）。在26例中的18例（64%），EGF-R浓度在95至230 fmol/mg prot. mb.之间。未发现EGF-R水平与肿瘤部位或组织病理学之间存在关联。唯一值得注意的观察结果是，与总体人群相比，3例间变性脑膜瘤中的EGF-R水平较低，以及血管性肿瘤中未检测到EGF-R水平。此外，未发现EGF-R水平与患者的激素状态之间存在相关性，也未发现EGF-R水平与同时检测的肿瘤内孕激素受体浓度之间存在相关性。在此背景下讨论了EGF-R在脑膜瘤中的生物学意义。
