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保护萌芽中的大脑 - 儿童神经重症监护。

Protecting the blossoming brain - Neurocritical care in children.

机构信息

University of Copenhagen, BRIC Biotech Research & Innovation Centre, Anders Lund Group, Copenhagen, Denmark.

出版信息

Biomed J. 2020 Jun;43(3):195-202. doi: 10.1016/j.bj.2020.06.005. Epub 2020 Jun 14.

DOI:10.1016/j.bj.2020.06.005
PMID:32600958
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7424088/
Abstract

This special issue of the Biomedical Journal is entirely dedicated to the latest updates regarding the medical efforts to preserve the fragile young brain after injury. Thereby, we learn about symptoms and diseases such as different forms of epilepsy, acute encephalopathy, increased intracranial pressure, and posthaemorrhagic hydrocephalus, as well as about their origins, such as infection, autoimmune diseases, preterm birth, or abusive head trauma. Moreover, diagnosis and surveillance techniques are discussed, including ultrasound of the optic nerve sheath diameter and multimodal monitoring. Finally, we discover various established and emerging therapeutic approaches, comprising target temperature management, ketogenic diet, and immunomodulation.

摘要

本期《生物医学期刊》特刊专门介绍了在受伤后保护脆弱的年轻大脑方面的医学最新进展。因此,我们了解了不同形式的癫痫、急性脑病、颅内压升高和出血后脑积水等症状和疾病,以及它们的起源,如感染、自身免疫性疾病、早产或虐待性头部创伤。此外,还讨论了诊断和监测技术,包括视神经鞘直径超声和多模态监测。最后,我们发现了各种已确立和新兴的治疗方法,包括目标温度管理、生酮饮食和免疫调节。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5579/7424088/474ab6a89b94/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5579/7424088/474ab6a89b94/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5579/7424088/474ab6a89b94/gr1.jpg

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Protecting the blossoming brain - Neurocritical care in children.保护萌芽中的大脑 - 儿童神经重症监护。
Biomed J. 2020 Jun;43(3):195-202. doi: 10.1016/j.bj.2020.06.005. Epub 2020 Jun 14.
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Measurement of optic nerve sheath diameter by ultrasound: a means of detecting acute raised intracranial pressure in hydrocephalus.超声测量视神经鞘直径:一种检测脑积水时急性颅内压升高的方法。
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Bedside sonographic measurement of optic nerve sheath diameter as a predictor of increased intracranial pressure in children.床边超声测量视神经鞘直径作为儿童颅内压升高的预测指标
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本文引用的文献

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Seizures severity during rewarming can predict seizure outcomes of infants with neonatal hypoxic-ischemic encephalopathy following therapeutic hypothermia.复温期间的惊厥严重程度可预测接受治疗性低温治疗的新生儿缺氧缺血性脑病婴儿的惊厥结局。
Biomed J. 2020 Jun;43(3):285-292. doi: 10.1016/j.bj.2020.06.008. Epub 2020 Jun 30.
2
Multimodal neurocritical monitoring.多模态神经重症监测。
Biomed J. 2020 Jun;43(3):226-230. doi: 10.1016/j.bj.2020.05.005. Epub 2020 May 28.
3
Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES).
发热感染相关癫痫综合征(FIRES)中 Toll 样受体反应减弱。
Biomed J. 2020 Jun;43(3):293-304. doi: 10.1016/j.bj.2020.05.007. Epub 2020 May 29.
4
Application of ketogenic diets for pediatric neurocritical care.生酮饮食在儿科神经危重症中的应用。
Biomed J. 2020 Jun;43(3):218-225. doi: 10.1016/j.bj.2020.02.002. Epub 2020 Jul 5.
5
Clinical application of target temperature management in children with acute encephalopathy-A practical review.目标温度管理在儿童急性脑病中的临床应用——实用综述。
Biomed J. 2020 Jun;43(3):211-217. doi: 10.1016/j.bj.2019.12.003. Epub 2020 Jun 28.
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Recent update in pediatric neurocritical care: Preface.儿科神经重症监护的最新进展:前言
Biomed J. 2020 Jun;43(3):203-204. doi: 10.1016/j.bj.2020.05.004. Epub 2020 May 23.
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Point-of-care ultrasound of optic nerve sheath diameter to detect intracranial pressure in neurocritically ill children - A narrative review.神经危重症患儿视神经鞘直径床边超声检测颅内压:叙述性综述。
Biomed J. 2020 Jun;43(3):231-239. doi: 10.1016/j.bj.2020.04.006. Epub 2020 Apr 23.
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Neurocritical care of premature infants.早产儿的神经重症监护
Biomed J. 2020 Jun;43(3):259-267. doi: 10.1016/j.bj.2020.03.007. Epub 2020 Apr 22.
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Neurocritical care and target immunotherapy for febrile infection-related epilepsy syndrome.神经危重症与发热感染相关癫痫综合征的靶向免疫治疗。
Biomed J. 2020 Jun;43(3):205-210. doi: 10.1016/j.bj.2020.03.009. Epub 2020 Apr 21.
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Therapeutic hypothermia for pediatric refractory status epilepticus May Ameliorate post-status epilepticus epilepsy.亚低温治疗儿童难治性癫痫持续状态可能改善癫痫持续后状态。
Biomed J. 2020 Jun;43(3):277-284. doi: 10.1016/j.bj.2020.04.004. Epub 2020 Apr 21.