Department of Ophthalmology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea.
Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea.
Sci Rep. 2020 Jun 29;10(1):10512. doi: 10.1038/s41598-020-67375-x.
We aimed to evaluate the association between obesity and the incidence of retinal vein occlusion (RVO) with and without diabetes mellitus (DM).This is a retrospective cohort study using Korean National Health Insurance System data. The participants were 23,061,531 adults older than 20 years who received a health examination at least once between 2009 and 2012, and all patients were observed for RVO development until 2015. We used a multivariate adjusted Cox regression analysis to evaluate the association between RVO and body mass index (BMI) with and without DM. The analysis were evaluated via a hazard ratio (HR) and 95% confidence interval (CI). The age-, sex-, and multivariable-adjusted HRs for RVO were stratified by BMI. This population-based study revealed evidence that obesity has a different effect on the incidence of RVO in the presence and absence of DM.In people with DM, a lower BMI was associated with an increased risk of RVO, and a higher BMI was associated with a lower risk for RVO. In people without DM, the correlation was reversed: a lower BMI was associated with a lower risk for RVO and vice versa.
评估肥胖与糖尿病（DM）合并或不合并视网膜静脉阻塞（RVO）发病的相关性。
这是一项回顾性队列研究，利用韩国国家健康保险系统的数据。纳入 2009 年至 2012 年间至少接受过一次健康体检且年龄超过 20 岁的 23061531 名成年人作为研究对象，所有患者均观察至 2015 年发生 RVO。采用多变量调整 Cox 回归分析评估 RVO 与 BMI（合并或不合并 DM）之间的相关性。采用风险比（HR）和 95%置信区间（CI）评估分析结果。根据 BMI 对年龄、性别和多变量调整后的 RVO 进行分层。
本基于人群的研究表明，肥胖对合并和不合并 DM 患者 RVO 的发病有不同的影响。在合并 DM 的患者中，较低的 BMI 与 RVO 风险增加相关，而较高的 BMI 与 RVO 风险降低相关。在不合并 DM 的患者中，相关性则相反：较低的 BMI 与 RVO 风险降低相关，反之亦然。
