使用韩国健康保险审查和评估数据库进行的全国性基于人群的研究：开角型青光眼患者视网膜静脉阻塞的发生率。

Incidence of retinal vein occlusion in open-angle glaucoma: a nationwide, population-based study using the Korean Health Insurance Review and Assessment Database.

机构信息

Department of Ophthalmology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea.

Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.

出版信息

Clin Exp Ophthalmol. 2018 Aug;46(6):637-644. doi: 10.1111/ceo.13157. Epub 2018 Feb 23.

DOI:10.1111/ceo.13157

PMID:29360215

Abstract

IMPORTANCE

We determined the association between retinal vein occlusion (RVO) and open-angle glaucoma (OAG) in a Korean population by reviewing a dataset obtained from the Korean Health Insurance Review and Assessment (HIRA).

BACKGROUND

To compare the RVO incidence for OAG patients with that for the general population in order to determine the association between RVO and OAG.

DESIGN

Nationwide population-based retrospective study.

PARTICIPANTS

HIRA data for 2011 through 2015.

METHODS

The HIRA data for 2011 through 2015 was analysed in order to determine the incidence rates of RVO in the general population and in OAG patients. The standardized incidence ratios (SIRs) of RVO for OAG patients were determined with respect to the age- and gender-matched general population.

MAIN OUTCOME MEASURES

SIRs of RVO.

RESULTS

The RVO incidence rate for the general population during the 4-year study period (2012-2015) was 74.16 per 100 000 person-years (95% confidence interval [CI], 73.79-74.54). A total of 272 143 OAG patients were identified in 2011 as the population at risk. The RVO incidence rate for the OAG patients was 528.95 per 100 000 person-years (95% CI, 515.46-542.79). The expected incidences of RVO in the OAG patients were 1760.66 during the 4-year study period. On the other hand, the observed incidences of RVO were 5758. The SIR of RVO for OAG patients in reference to the general population was 3.27 (95% CI, 3.19-3.35).

CONCLUSIONS AND RELEVANCE

The RVO incidence rate for OAG patients is significantly higher than that for the general population.

摘要

重要性

我们通过审查韩国健康保险审查与评估（HIRA）获得的数据集，确定了韩国人群中视网膜静脉阻塞（RVO）与开角型青光眼（OAG）之间的关联。

背景

为了比较 OAG 患者的 RVO 发生率与普通人群的发生率，以确定 RVO 与 OAG 之间的关系。

设计

全国性基于人群的回顾性研究。

参与者

HIRA 2011 年至 2015 年的数据。

方法

分析 HIRA 2011 年至 2015 年的数据，以确定普通人群和 OAG 患者的 RVO 发生率。用年龄和性别匹配的普通人群来确定 OAG 患者 RVO 的标准化发病比（SIR）。

主要观察指标

RVO 的 SIR。

结果

在 4 年的研究期间（2012-2015 年），普通人群的 RVO 发病率为 74.16/10 万人年（95%置信区间[CI]，73.79-74.54）。2011 年共确定了 272143 例 OAG 患者作为风险人群。OAG 患者的 RVO 发病率为 528.95/10 万人年（95%CI，515.46-542.79）。在 4 年的研究期间，OAG 患者 RVO 的预期发生率为 1760.66。然而，观察到的 RVO 发生率为 5758。OAG 患者 RVO 的 SIR 相对于普通人群为 3.27（95%CI，3.19-3.35）。