肺癌患者中无狼疮表现的抗史密斯抗体阳性
Anti-Smith Antibody Positivity Without Lupus in the Setting of Lung Cancer.
作者信息
Timlin Homa, Machireddy Kirthi, Shiroky Jennifer, Ravi Srekar, Haque Uzma
机构信息
Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, USA.
Osteopathic Medicine, Edward Via College of Osteopathic Medicine, Blacksburg, USA.
出版信息
Cureus. 2020 May 26;12(5):e8298. doi: 10.7759/cureus.8298.
The interpretation of positive serologic findings in cancer sera remains controversial. Selected antinuclear antibodies (ANAs), such as anti-double-stranded deoxyribonucleic acid (dsDNA) and anti-Smith, are highly specific for the diagnosis of systemic lupus erythematosus (SLE). On the other hand, the ANA titer is sensitive but not specific for SLE and has been reported in healthy individuals, various infections, other autoimmune diseases and cancer. We report for the first time positive anti-Smith antibody in two patients without lupus in the setting of lung cancer.
癌症血清学检查结果呈阳性的解读仍存在争议。某些抗核抗体（ANA），如抗双链脱氧核糖核酸（dsDNA）抗体和抗史密斯抗体，对系统性红斑狼疮（SLE）的诊断具有高度特异性。另一方面，ANA滴度对SLE敏感但不具有特异性，且在健康个体、各种感染、其他自身免疫性疾病及癌症患者中均有报道。我们首次报告了两名非狼疮患者在患肺癌时出现抗史密斯抗体阳性的情况。
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