Frountzas Maximos, Karathanasis Panagiotis, Vrakopoulou Gavriella Zoi, Theodoropoulos Charalampos, Zografos Constantinos G, Schizas Dimitrios, Zografos George C, Michalopoulos Nikolaos V
1st Department of Propaedeutic Surgery, Medical School, "Hippocratio" General Hospital, University of Athens, 114 Vas. Sophias Av, 11527, Athens, Greece.
1st Department of Surgery, Medical School, University of Athens, "Laiko" General Hospital, 17 Agiou Thoma St, 11527, Athens, Greece.
Breast Cancer. 2020 Nov;27(6):1191-1197. doi: 10.1007/s12282-020-01129-5. Epub 2020 Jun 29.
Kounis syndrome (KS) has been described as an acute coronary syndrome (ACS) associated with an anaphylactic reaction. Several triggers have been identified and the diagnostic and treatment process can be challenging.
A 58-year-old, female patient diagnosed with breast cancer and no history of allergies had subcutaneous injection of patent blue V dye for sentinel lymph node biopsy (SLNB). Intraoperatively, she developed anaphylactic shock and was transferred to the intensive care unit (ICU). A few hours later, electrocardiographic alterations and elevation of blood troponin were observed. Emergency coronary angiography revealed no occlusive lesions in coronary vessels. Further investigation in the allergy department set the diagnosis of KS.
There are just ten cases of perioperative KS in the literature so far and here we present the first one triggered by patent blue V dye for sentinel node biopsy.
库尼斯综合征（KS）被描述为一种与过敏反应相关的急性冠状动脉综合征（ACS）。已确定多种触发因素，其诊断和治疗过程可能具有挑战性。
一名58岁女性患者，被诊断患有乳腺癌且无过敏史，在进行前哨淋巴结活检（SLNB）时皮下注射了专利蓝V染料。术中，她发生过敏性休克并被转入重症监护病房（ICU）。数小时后，观察到心电图改变及血肌钙蛋白升高。急诊冠状动脉造影显示冠状动脉血管无闭塞性病变。过敏科的进一步检查确诊为KS。
迄今为止，文献中仅有10例围手术期KS病例，在此我们报告首例由专利蓝V染料用于前哨淋巴结活检引发的KS病例。
