Wang Tianyou, Xu Yan, Shao Wenyu, Wang Chao
Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Front Med (Lausanne). 2022 Jun 29;9:922585. doi: 10.3389/fmed.2022.922585. eCollection 2022.
The sentinel lymph nodes (SLNs) is a group of lymph nodes initially involved in the metastatic spread of cancer cells. SLN mapping refers to intraoperative localization and biopsy of SLNs with specific tracers to assess lymph node metastases. It is widely used in a variety of tumor surgeries for its high sensitivity and high negative predictive value. In the evaluation of the status of lymph node metastases in gynecological malignancies, it has received increasingly more attention due to its minor invasiveness, few complications, and high diagnosis rate. The National Comprehensive Cancer Network (NCCN) guidelines provide an excellent introduction to the indications and methods of SLN techniques in vulvar, cervical, and endometrial cancers, but they provide little explanation about some specific issues. In this review, we summarize different dyes and injection methods and discuss the indications of application and the clinical trials of SLN mapping in gynecological malignant tumors, aiming to provide a reference for the rational application of sentinel techniques in gynecology malignant tumors before relevant guidelines are updated.
前哨淋巴结（SLNs）是最初参与癌细胞转移扩散的一组淋巴结。前哨淋巴结定位是指术中使用特定示踪剂对前哨淋巴结进行定位和活检，以评估淋巴结转移情况。因其高敏感性和高阴性预测值，它在各种肿瘤手术中得到广泛应用。在评估妇科恶性肿瘤的淋巴结转移状态时，由于其微创性、并发症少和诊断率高，它受到了越来越多的关注。美国国立综合癌症网络（NCCN）指南对外阴癌、宫颈癌和子宫内膜癌中前哨淋巴结技术的适应证和方法进行了很好的介绍，但对一些具体问题的解释很少。在本综述中，我们总结了不同的染料和注射方法，并讨论了前哨淋巴结定位在妇科恶性肿瘤中的应用适应证和临床试验，旨在在相关指南更新之前，为前哨淋巴结技术在妇科恶性肿瘤中的合理应用提供参考。
