Wang Na, Dong Xiujuan, Shi Dandan, Li Na, Zhang Qun
Department of Obstetrics, Cangzhou Central Hospital, No. 16 Xinhua Western Road, Cangzhou, 061000, Hebei, China.
Dermatological Department, Cangzhou People's Hospital, No. 7 Qingchi Avenue, Cangzhou, 061000, Hebei, China.
Arch Pharm Res. 2020 Jul;43(7):755-764. doi: 10.1007/s12272-020-01242-1. Epub 2020 Jun 29.
Gestational diabetes mellitus (GDM) is a conditional diabetes which is defined as any degree of glucose intolerance or high blood glucose levels during any phase of pregnancy. It causes chronic severe damage to health of the pregnant women and their offspring. In this study, we aimed to study the protective effects of Cryptotanshinone on GDM-related impairments. We measured blood glucose levels, serum insulin levels, biochemical indexes, oxidative stress, inflammation and the activation of NF-κB signaling pathway in the blood and placenta of GDM mice. It is found that Cryptotanshinone significantly decreased blood glucose levels, oxidative stress, inflammation and NF-κB signaling with an increase of serum insulin levels in the placenta and blood of GDM mice. Taken together, Cryptotanshinone effectively ameliorated GDM, which suggested that Cryptotanshinone could be served as a promising therapeutic drug for GDM patients.
妊娠期糖尿病（GDM）是一种条件性糖尿病，定义为妊娠任何阶段出现的任何程度的葡萄糖不耐受或高血糖水平。它会对孕妇及其后代的健康造成慢性严重损害。在本研究中，我们旨在研究隐丹参酮对GDM相关损伤的保护作用。我们测量了GDM小鼠血液和胎盘中的血糖水平、血清胰岛素水平、生化指标、氧化应激、炎症以及NF-κB信号通路的激活情况。结果发现，隐丹参酮显著降低了GDM小鼠胎盘和血液中的血糖水平、氧化应激、炎症和NF-κB信号，同时血清胰岛素水平升高。综上所述，隐丹参酮有效改善了GDM，这表明隐丹参酮有望成为治疗GDM患者的药物。
