Chen Yangyang, Tang Jichun, Zhang Yinghong, Du Juan, Wang Yuanli, Yu Hui, He Yanling
Department of Obstetrics, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, No. 20 Yuhuangding East Road, Yantai, 264000, Shandong, China.
Department of Obstetrics, Penglai Traditional Chinese Medicine Hospital, Penglai, 265600, Shandong, China.
Naunyn Schmiedebergs Arch Pharmacol. 2020 Dec;393(12):2517-2527. doi: 10.1007/s00210-020-01861-x. Epub 2020 Apr 11.
Gestational diabetes mellitus (GDM) affects 7% of pregnant women worldwide, which increases the risk of diabetes and cardiovascular disease for both the mother and the fetus. Natural compound Astaxanthin has been reported to have benefits in obesity and diabetes. A pregnant C57BL/KsJ db/+ mouse was used as a genetic GDM model to investigate the effect of Astaxanthin on GDM symptoms and reproductive outcomes. Blood glucose, plasma insulin, glucose intolerance, insulin sensitivity, biochemical indexes of plasma, and the liver were measured; Nrf2 and HO-1 protein levels were detected by Western blotting. Astaxanthin significantly alleviated the glucose intolerance and β cell insufficiency, inhibited in vivo oxidative stress, enhanced the activity of antioxidant enzymes, and improved reproductive outcomes. Mechanistically, the effect of Astaxanthin was mediated by restoring the Nrf2/HO-1 antioxidant pathway in the liver of GDM mice. Our findings supported that Astaxanthin was a potential therapeutic reagent for not only diabetes but also GDM symptomology.
妊娠期糖尿病（GDM）影响着全球7%的孕妇，这增加了母亲和胎儿患糖尿病及心血管疾病的风险。据报道，天然化合物虾青素对肥胖和糖尿病有益。将一只怀孕的C57BL/KsJ db/+小鼠作为遗传性GDM模型，以研究虾青素对GDM症状和生殖结局的影响。测量了血糖、血浆胰岛素、葡萄糖耐量、胰岛素敏感性、血浆和肝脏的生化指标；通过蛋白质印迹法检测Nrf2和HO-1蛋白水平。虾青素显著减轻了葡萄糖耐量异常和β细胞功能不全，抑制了体内氧化应激，增强了抗氧化酶的活性，并改善了生殖结局。从机制上讲，虾青素的作用是通过恢复GDM小鼠肝脏中的Nrf2/HO-1抗氧化途径来介导的。我们的研究结果支持虾青素不仅是糖尿病的潜在治疗试剂，也是GDM症状的潜在治疗试剂。
