Department of Orthopedic Surgery and Rare Diseases Institute, Korea University Medical College, Korea University Guro Hospital, Seoul, Republic of Korea.
Department of Systems Biotechnology, Chung-Ang University, Anseong-si, Gyeonggi-do, Republic of Korea.
Adv Exp Med Biol. 2020;1250:177-188. doi: 10.1007/978-981-15-3262-7_12.
Biphasic calcium phosphate bioceramics consist of an intimate mixture of hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) in varying ratios. Due to their biocompatibility, osteoconductivity, and safety in in vitro, in vivo, and clinical models, they have become promising bone substitute biomaterials and are recommended for use as alternatives for or as additives in bone tissue regeneration in various orthopedic and dental applications. Many studies have demonstrated the potential uses of BCP bioceramics as scaffolds for tissue engineering. Here, we highlight the recent advances in the uses of BCP bioceramics and functionalized BCPs for bone tissue regeneration.
双相磷酸钙生物陶瓷由羟基磷灰石（HA）和β-磷酸三钙（β-TCP）以不同比例组成的紧密混合物。由于其在体外、体内和临床模型中的生物相容性、骨传导性和安全性，它们已成为有前途的骨替代生物材料，并被推荐用于各种骨科和牙科应用中替代或作为骨组织再生的添加剂。许多研究已经证明了 BCP 生物陶瓷作为组织工程支架的潜在用途。在这里，我们重点介绍了 BCP 生物陶瓷和功能化 BCP 用于骨组织再生的最新进展。
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