Integrative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Malaysia.
School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Nibong Tebal, Malaysia.
J Biomed Mater Res B Appl Biomater. 2021 Oct;109(10):1426-1435. doi: 10.1002/jbm.b.34802. Epub 2021 Jan 22.
Autologous bone grafting remains the gold standard for almost all bone void-filling orthopedic surgery. However, autologous bone grafting has several limitations, thus scientists are trying to identify an ideal synthetic material as an alternative bone graft substitute. Magnesium-doped biphasic calcium phosphate (Mg-BCP) has recently been in the spotlight and is considered to be a potential bone substitute. The Mg-BCP is a mixture of two bioceramics, that is, hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), doped with Mg , and can be synthesized through chemical wet-precipitation, sol-gel, single diffusion gel, and solid state reactions. Regardless of the synthesis routes, it is found that the Mg preferentially accommodates in β-TCP lattice instead of the HA lattice. The addition of Mg to BCP leads to desirable physicochemical properties and is found to enhance the apatite-forming ability as compared to pristine BCP. In vitro results suggest that the Mg-BCP is bioactive and not toxic to cells. Implantation of Mg-BCP in in vivo models further affirmed its biocompatibility and efficacy as a bone substitute. However, like the other bioceramics, the optimum physicochemical properties of the Mg-BCP scaffold have yet to be determined. Further investigations are required regarding Mg-BCP applications in bone tissue engineering.
自体骨移植仍然是几乎所有骨缺损填充骨科手术的金标准。然而，自体骨移植有几个局限性，因此科学家们正在努力寻找一种理想的合成材料作为替代骨移植替代物。掺镁双相磷酸钙（Mg-BCP）最近成为焦点，被认为是一种有潜力的骨替代物。Mg-BCP 是两种生物陶瓷（即羟基磷灰石（HA）和 β-磷酸三钙（β-TCP））的混合物，掺入了 Mg，可以通过化学湿沉淀法、溶胶-凝胶法、单扩散凝胶法和固态反应法合成。无论采用哪种合成路线，都发现 Mg 优先进入 β-TCP 晶格而不是 HA 晶格。BCP 中添加 Mg 会导致理想的物理化学性质，并发现与原始 BCP 相比，它能增强磷灰石形成能力。体外结果表明，Mg-BCP 具有生物活性且对细胞无毒。在体内模型中植入 Mg-BCP 进一步证实了其作为骨替代物的生物相容性和功效。然而，与其他生物陶瓷一样，Mg-BCP 支架的最佳物理化学性质尚未确定。需要进一步研究 Mg-BCP 在骨组织工程中的应用。
