Department of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Ul. Banacha 1, 02-097, Warsaw, Poland.
Biol Trace Elem Res. 2023 Dec;201(12):5640-5651. doi: 10.1007/s12011-023-03631-1. Epub 2023 Apr 1.
Zinc is a micronutrient of key importance for human health. An increasing number of studies indicate that zinc plays a significant role in bone tissue's normal development and maintaining homeostasis. Zinc is not only a component of bone tissue but is also involved in the synthesis of the collagen matrix, mineralization, and bone turnover. It has been demonstrated that zinc can stimulate runt-related transcription factor 2 (Runx2) and promote the differentiation of osteoblasts. On the other hand, zinc has been found to inhibit osteoclast-like cell formation and to decrease bone resorption by stimulating osteoclasts' apoptosis. Moreover, zinc regulates the RANKL/RANK/OPG pathway, thereby facilitating bone remodeling. To date, not all mechanisms of Zn activity on bone tissue are well understood and documented. The review aimed to present the current state of research on the role of zinc in bone tissue, its beneficial properties, and its effects on bone regeneration. Since calcium phosphates as bone substitute materials are increasingly enriched in zinc ions, the paper included an overview of research on the potential role of such materials in bone filling and regeneration.
锌是人体健康的重要微量元素。越来越多的研究表明，锌在骨骼组织的正常发育和维持体内平衡中起着重要作用。锌不仅是骨骼组织的组成部分，还参与胶原蛋白基质的合成、矿化和骨转换。研究表明，锌可以刺激 runt 相关转录因子 2（Runx2）并促进成骨细胞的分化。另一方面，锌通过刺激破骨细胞凋亡来抑制破骨细胞样细胞的形成和减少骨吸收。此外，锌调节 RANKL/RANK/OPG 通路，从而促进骨重塑。迄今为止，锌对骨骼组织的作用的所有机制尚未得到充分理解和记录。本综述旨在介绍锌在骨骼组织中的作用、有益特性及其对骨再生的影响的研究现状。由于钙磷作为骨替代材料中越来越多地富集锌离子，本文还概述了研究此类材料在骨填充和再生中的潜在作用。
