产前暴露于孤立的羊水疾病与子代长期内分泌疾病风险
Prenatal exposure to isolated amniotic fluid disorders and the risk for long-term endocrine morbidity of the offspring.
作者信息
Pariente Gali, Walfisch Asnat, Wainstock Tamar, Landau Daniella, Sergienko Ruslan, Sheiner Eyal
机构信息
Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, POB 151, 84101, Beer-Sheva, Israel.
Department of Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
出版信息
Arch Gynecol Obstet. 2020 Oct;302(4):873-878. doi: 10.1007/s00404-020-05674-4. Epub 2020 Jun 29.
BACKGROUND
Amniotic fluid abnormalities may be associated with adverse perinatal outcomes, some of which are endocrine related.
OBJECTIVE
To evaluate whether in utero exposure to amniotic fluid abnormalities is associated with long-term endocrine morbidity in the offspring.
STUDY DESIGN
In this cohort study, the incidence of long-term endocrine disorders was compared between singletons exposed and non-exposed to oligohydramnios or polyhydramnios.
RESULTS
During the study period, 195 943 newborns were included in the study, of them 2.0% (n = 4072) and 2.9% (n = 5684) were exposed to oligohydramnios and polyhydramnios, respectively. Long-term endocrine morbidity was higher among children exposed to isolated amniotic fluid disorders, as was also noted in the Kaplan-Meier survival curve (log-rank test p < 0.001). Abnormal amniotic fluid volume was found to be independently associated with long-term endocrine morbidity of the offspring according to a Cox regression model controlled for clinically related confounders.
CONCLUSION
In utero exposure to isolated amniotic fluid abnormalities is independently associated with long-term endocrine morbidity in the offspring.
背景
羊水异常可能与不良围产期结局相关，其中一些与内分泌有关。
目的
评估子宫内暴露于羊水异常是否与后代的长期内分泌疾病相关。
研究设计
在这项队列研究中，比较了暴露于羊水过少或羊水过多的单胎与未暴露的单胎中远期内分泌疾病的发生率。
结果
在研究期间，共有195943例新生儿纳入研究，其中2.0%（n = 4072）和2.9%（n = 5684）分别暴露于羊水过少和羊水过多。暴露于单纯羊水疾病的儿童中远期内分泌疾病发生率更高，在Kaplan-Meier生存曲线中也有体现（对数秩检验p < 0.001）。根据控制了临床相关混杂因素的Cox回归模型，发现羊水量异常与后代的远期内分泌疾病独立相关。
结论
子宫内暴露于单纯羊水异常与后代的远期内分泌疾病独立相关。
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